Results 111 to 120 of about 2,146,795 (300)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A new reverse Mulholland’s inequality with one partial sum in the kernel

open access: yesJournal of Inequalities and Applications
By means of the techniques of real analysis, applying some basic inequalities and formulas, a new reverse Mulholland’s inequality with one partial sum in the kernel is given. We obtain the equivalent conditions of the parameters related to the best value
Xianyong Huang   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Evaluation of some reciprocal trigonometric sums via partial fraction decomposition

open access: yesKuwait Journal of Science, 2020
Recently, Melham computed some nite sums in which the denominator of the summand includes products of `sine' or `cosine'. In this paper, generalizations of the sums, which he studied in 2016, are presented, by allowing arbitrary factors in the ...
Talha Arıkan, Helmut Prodinger
doaj  

Proof without words: The sum (formula presented) and its partial sums

open access: yes, 2016
We provide a visual proof of the identity (formula presented) including its partial sums.
Ciaurri, Ó. [0000-0002-1695-3311]
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Maximal estimates for strong arithmetic means of Fourier series

open access: yesAdvanced Nonlinear Studies
It is well-understood that partial sums of Fourier series for L 1 functions don’t necessarily converge to the original function in the pointwise-almost everywhere sense.
Wilson Bobby
doaj   +1 more source

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