Results 131 to 140 of about 2,300,073 (304)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Lp-approximations of weighted partial sum processes

We prove an optimal asymptotic result for weighted Lp-distance of partial sum processes of independent identically distributed random variables. Using this result, we prove also the convergence in distribution of weighted Lp-functionals of U-statistic ...
Szyszkowicz, Barbara
core  

Partial Sum Minimization of Singular Values Representation on Grassmann Manifolds

, 2018
Clustering is one of the fundamental topics in data mining and pattern recognition. As a prospective clustering method, the subspace clustering has made considerable progress in recent researches, e.g., sparse subspace clustering (SSC) and low rank ...
Yanfeng Sun, Junbin Gao, Yongli Hu, Boyue Wang, Baocai Yin   +4 more
core   +1 more source

Sign changes of the partial sums of a random multiplicative function II

Comptes Rendus. Mathématique
We study two models of random multiplicative functions: Rademacher random multiplicative functions supported on the squarefree integers $f$, and Rademacher random completely multiplicative functions $f^*$. We prove that the partial sums $\sum _{n\le x}f^*
Aymone, Marco
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial Soft Derivative

Communications in Advanced Mathematical Sciences
The concept of soft derivative, introduced by Molodtsov in 1999, is one of the fundamental concepts in soft analysis. The handled paper defines partial soft derivative and studies some of its basic properties, such as the relation between partial soft ...
Serdar Enginoğlu, Burak Arslan
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source