Results 141 to 150 of about 2,146,795 (300)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Weak solutions for anisotropic nonlinear elliptic equations with variable exponents
Electronic Journal of Differential Equations, 2009 We study the anisotropic boundary-value problem $$displaylines{ -sum^{N}_{i=1}frac{partial}{partial x_{i}}a_{i}(x,frac{partial}{partial x_{i}}u)=f quad hbox{in } Omega, cr u=0 quadhbox{on }partial Omega, }$$ where $Omega$ is a smooth bounded ...
Sado Traore +2 more
doaj
Connectedness of Kronecker sum and partial Kronecker row sum of designs
In this paper we discuss connectedness of a design which is a Kronecker sum or a partial Kronecker row sum of any two equi-replicate and equi-block size designs.Kronecker sum partial Kronecker sum connectedness balanced ...
Dandawate, P. N. +2 more
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Max-Sum Decentralised Coordination for Sensor Systems
, 2008 A key challenge for the successful deployment of systems consisting of multiple autonomous networked sensors is the development of decentralised mechanisms to coordinate the activities of these physically distributed devices in order to achieve good ...
Farinelli, A. +17 more
core +1 more source