Results 161 to 170 of about 2,300,073 (304)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

SOLUTIONS FOR OPTIMIZING THE DATA PARALLEL PREFIX SUM ALGORITHM USING THE COMPUTE UNIFIED DEVICE ARCHITECTURE [PDF]

In this paper, we analyze solutions for optimizing the data parallel prefix sum function using the Compute Unified Device Architecture (CUDA) that provides a viable solution for accelerating a broad class of applications. The parallel prefix sum function
Alexandru Pîrjan, Dana-Mihaela Petroşanu, Ion Lungu   +2 more
core  

How reliable is deep inspiration breath hold at CT simulation? Clinical impact of surface-guided breathing training in breast cancer radiotherapy. [PDF]

Radiat Oncol
Dietrich L, Lackner N, Karius A, Brand J, Lobao R, Huseynli A, Ott OJ, Corradini S, Fietkau R, Bert C, Shariff M.   +10 more
europepmc   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Clinical insight in schizophrenia: Time-specific associations with symptoms, cognition and antipsychotic mechanisms. [PDF]

Schizophr Res Cogn
Stabell LA, Johnsen E, Kroken RA, Løberg EM, Joa I, Reitan SK, Rettenbacker M, Gjestad R.   +7 more
europepmc   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Ranking by weighted sum

When choosing an alternative that has multiple attributes, it is common to form a weighted sum ranking. In this paper, we provide an axiomatic analysis of the weighted sum criterion using a general choice framework.
Ozbek, Kemal, Mitra, Tapan
core   +1 more source

Intrinsic timescale develops hierarchically from sensorimotor to association cortex in youth and stabilizes in adulthood. [PDF]

PLoS Biol
Shafiei G, Bagautdinova J, Sydnor VJ, Bassett DS, Barch DM, Cieslak M, Fan Y, Flook E, Franco AR, Kiar G, Luo AC, Milham MP, Parkes L, Salo T, Somerville LH, Tong TT, Shinohara RT, Satterthwaite TD.   +17 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source