Results 51 to 60 of about 24,654 (279)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

PAPR Reduction of OFDM Signals by Novel Global Harmony Search in PTS Scheme

International Journal of Digital Multimedia Broadcasting, 2012
The orthogonal frequency division multiplexing (OFDM) modulation technique is one of the key strategies for multiuser signal transmission especially in smart grids and wind farms.
Hojjat Salehinejad, Siamak Talebi
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A low PAPR performance with new segmentation schemes of partial transmit sequence for OFDM systems

, 2017
Despite the fact that OFDM has numerous features, the high peak-to-average power ratio (PAPR) deems one of the challenging disadvantages face by the system in the real applications.
Yasir Amer Jawhar, N. Shah, M. A. Taher, K. N. Ramli, Mustafa Sami Ahmed, R. A. Abdulhasan   +5 more
semanticscholar   +1 more source

Optimizing PAPR performance for 6G OTFS waveform using adaptive genetic PTS method for Rician fading channels

EURASIP Journal on Advances in Signal Processing
This paper proposes a novel method for reducing the peak-to-average power ratio (PAPR) in orthogonal time–frequency space (OTFS) modulation over Rician fading channels using an adaptive genetic algorithm-based partial transmit sequence (AGA-PTS ...
Arun Kumar, Aziz Nanthaamornphong, Nishant Gaur   +2 more
doaj   +1 more source

NORM Technique based PAPR Reduction in MC-CDMA Systems

Journal of ICT Research and Applications, 2015
Multicarrier code division multiple access (MC-CDMA) is one of the promising technologies for future-generation wireless networks. It offers high data rates, protection against frequency-selective fading and efficient utilization of the spectrum.
Noor Mohammed Vali Mohamad, P. S Mallick, L. Nithyanandan, Srujan Dharmagadda, M. Surendrakumar, M. Palanivelan   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Genetic algorithm-based PTS with CNN for PAPR and BER reduction in FBMC systems under fading channels

Ain Shams Engineering Journal
The Filter Bank Multicarrier (FBMC) is a promising candidate for next-generation wireless systems because of its superior spectral efficiency and resilience to synchronization errors.
Arun Kumar, Aziz Nanthaamornphong
doaj   +1 more source