Results 71 to 80 of about 190,014 (273)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Genetic algorithm-based PTS with CNN for PAPR and BER reduction in FBMC systems under fading channels

Ain Shams Engineering Journal
The Filter Bank Multicarrier (FBMC) is a promising candidate for next-generation wireless systems because of its superior spectral efficiency and resilience to synchronization errors.
Arun Kumar, Aziz Nanthaamornphong
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Low-Complexity Distortionless Techniques for Peak Power Reduction in OFDM Communication Systems

Journal of Computer Networks and Communications, 2012
A high peak-to-average power ratio (PAPR) is one of the major drawbacks to using orthogonal frequency division multiplexing (OFDM) modulation. The three most effective distortionless techniques for PAPR reduction are partial transmit sequence (PTS ...
A. Ghassemi, T. A. Gulliver
doaj   +1 more source

Low-Complexity PTS Scheme for Improving PAPR Performance of OFDM Systems

IEEE Access, 2019
Orthogonal frequency division multiplexing (OFDM) has been one of the mainstream technologies in the fields of modern wireless communications. However, its own high peak to average power ratio (PAPR) problem can impair the performance of system, which ...
Zhuang Zhou, Lingyin Wang, Chi Hu
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Joint Source-Channel Coding over a Fading Multiple Access Channel with Partial Channel State Information

, 2009
In this paper we address the problem of transmission of correlated sources over a fast fading multiple access channel (MAC) with partial channel state information available at both the encoders and the decoder.
Rajesh, R, Sharma, Vinod
core  

Partial Transmit Sequences for Peak-to-Average Power Ratio Reduction in Multiantenna OFDM

EURASIP Journal on Wireless Communications and Networking, 2007
The major drawback of orthogonal frequency-division multiplexing (OFDM) is its high peak-to-average power ratio (PAR), which gets even more substantial if a transmitter with multiple antennas is considered. To overcome this problem, in this paper, the partial transmit sequences (PTS) method—well known for PAR reduction in single antenna systemsâ€
Christian Siegl, Robert F. H. Fischer
openaire   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source