Results 81 to 90 of about 679,842 (277)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Best Proximity Point for the Sum of Two Non-Self-Operators
Journal of Mathematics, 2020 In the present paper, we focus our attention on the existence of the fixed point for the sum of the cyclic contraction and the noncyclic accretive operator. Also, we study the best proximity point for the sum of two non-self-mappings.
V. Pragadeeswarar, R. Gopi, M. De la Sen
doaj +1 more source
An update on the middle levels problem
, 2006 The middle levels problem is to find a Hamilton cycle in the middle levels, M_{2k+1}, of the Hasse diagram of B_{2k+1} (the partially ordered set of subsets of a 2k+1-element set ordered by inclusion).
Savage, Carla D. +2 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The solution of super-scale DEA models based on preference character
Alexandria Engineering JournalThe basic relationships and intrinsic laws in the data envelopment analysis (DEA) are the basis for designing fast solutions for big data DEA models.
Zhanxin Ma, Hao Li, Yinjie, Ziwei Fan
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Coupled fixed point results for $alpha$-admissible Mizoguchi-Takahashi contractions in $b$-metric spaces with applications [PDF]
Sahand Communications in Mathematical Analysis, 2017 The aim of this paper is to establish some fixed point theorems for $alpha$-admissible Mizoguchi-Takahashi contractive mappings defined on a ${b}$-metric space which generalize the results of Gordji and Ramezani cite{Roshan6}.
Vahid Parvaneh +3 more
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