Results 101 to 110 of about 1,432,735 (299)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Work Experience: Participation or Creation?

Psychology, 2014
Where does the successful performance of businesses and organizations mostly stem from? Is it from engagement in work or an effort undergoing imposed expectations? The latter has been a matter of much controversy. Proposals for participation in the workplace were a target of much criticism by Castoriadis and Tragtemberg.
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Reflections From Participants Who Participated in a Photovoice Study: The Importance of Flexibility and Individualization

International Journal of Qualitative Methods
Participant feedback can help researchers identify aspects to consider and improve in the design of future studies. In this study, we explored the experiences and perceptions of participants who participated in a photovoice study, and their thoughts on ...
Hardeep Singh, Kristina M. Kokorelias, Jill I. Cameron, Sarah Munce, Heather Colquhoun, Carolyn Steele Gray, Terence Tang, M. Patrice Lindsay, Michelle L. A. Nelson   +8 more
doaj   +1 more source

Use of the STAR PROCESS for Children with Sensory Processing Challenges [PDF]

, 2019
Background: This study examined the effectiveness of the STAR PROCESS, an intensive, short-term intervention that combines principles of sensory integration, relationship-based therapy, and parental-therapist collaboration for children with sensory ...
Camarata, Stephen, Miller, Lucy Jane, Schoen, Sarah A, Valdez, Andrea   +3 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Qualitative Digital Diary Methods: Participant-Led Values for Ethical and Insightful Mental Health Research

International Journal of Qualitative Methods
Qualitative digital diary methods are a promising tool for capturing participants’ experiences in their own words and over time. The use of smartphone apps to collect this kind of data provides an accessible and flexible way to participate in research ...
Catherine McCombie, Georgina Miguel Esponda, Hannah Ouazzane, Gemma Knowles, Charlotte Gayer-Anderson, Ulrike Schmidt, Vanessa Lawrence   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Participation in Researches with Participative Methodologies: Reflections about Experiences

, 2018
Objective: Thus, this article seeks to provoke new reflections about participation, based on some research experiences with participatory methodology. Methods: The steps for the composition of this reflection were: 1-) selection of significant characteristics from the experiences during research with participatory methodologies 2-) presentation and ...
Gatto Júnior, José Renato, Sousa, Leandra Andréia De, Pesce, Sébastien, Fortuna, Cinira Magali   +3 more
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source