Results 1 to 10 of about 52,724 (260)

Ethical and practical considerations for mitigating risks to sexual partners during analytical treatment interruptions in HIV cure-related research [PDF]

HIV Research & Clinical Practice, 2021
Background Background: Analytical treatment interruptions (ATIs) in HIV cure-related research can result in trial participants becoming viremic with HIV, placing HIV-negative sexual partners at elevated risk of acquiring HIV.
Karine Dubé, John Kanazawa, Lynda Dee, Jeff Taylor, Danielle M. Campbell, Brandon Brown, Mallory O. Johnson, Parya Saberi, John A. Sauceda, Jeremy Sugarman, Michael J. Peluso   +10 more
doaj   +8 more sources

Understanding participant perspectives around HIV-1 cure-related studies involving antiretroviral analytical treatment interruptions in the United Kingdom [PDF]

Journal of Virus Eradication, 2023
Background: To test efficacy, HIV cure-related trials often require a period of intensively monitored interruption of antiretroviral therapy (ART) (analytical treatment interruption or ATI).
Ming J. Lee, Piyumika Godakandaarachchi, Simon Collins, Mariusz Racz, Alice Sharp, Sarah Fidler, Julie Fox   +6 more
doaj   +4 more sources

Transient viral replication during analytical treatment interruptions in SIV infected macaques can alter the rebound-competent viral reservoir. [PDF]

PLoS Pathogens, 2021
Analytical treatment interruptions (ATIs) of antiretroviral therapy (ART) play a central role in evaluating the efficacy of HIV-1 treatment strategies targeting virus that persists despite ART.
Taina T Immonen, Christine M Fennessey, Leslie Lipkey, Abigail Thorpe, Gregory Q Del Prete, Jeffrey D Lifson, Miles P Davenport, Brandon F Keele   +7 more
doaj   +4 more sources

Participant experiences using novel home-based blood collection device for viral load testing in HIV cure trials with analytical treatment interruptions [PDF]

HIV Research & Clinical Practice, 2022
Background: HIV cure-directed clinical trials using analytical treatment interruptions (ATIs) require participants to adhere to frequent monitoring visits for viral load tests.
Karine Dubé, Harsh Agarwal, William B. Carter, Lynda Dee, Jeff Taylor, Christopher Roebuck, Beth Peterson, Hursch Patel, Samuel Ndukwe, Kenneth M. Lynn, Linden Lalley-Chareczko, Emily Hiserodt, Sukyung Kim, Daniel Rosenbloom, Brad R. Evans, Melanie Anderson, Daria J. Hazuda, Kevin Bateman, Bonnie J. Howell, Livio Azzoni, Karam Mounzer, Pablo Tebas, Luis J. Montaner   +22 more
doaj   +2 more sources

“We are looking at the future right now”: community acceptability of a home-based viral load test device in the context of HIV cure-related research with analytical treatment interruptions in the United States [PDF]

HIV Research & Clinical Practice, 2022
Background People with HIV (PWH) and community members have advocated for the development of a home-based viral load test device that could make analytical treatment interruptions (ATIs) less burdensome. Objective We assessed community acceptability of a
Karine Dubé, John Kanazawa, Christopher Roebuck, Steven Johnson, William B. Carter, Lynda Dee, Beth Peterson, Kenneth M. Lynn, Linden Lalley-Chareczko, Emily Hiserodt, Sukyung Kim, Daniel Rosenbloom, Brad R. Evans, Melanie Anderson, Daria J. Hazuda, Lisa Shipley, Kevin Bateman, Bonnie J. Howell, Karam Mounzer, Pablo Tebas, Luis J. Montaner   +20 more
doaj   +2 more sources

“It comes altogether as one:” perceptions of analytical treatment interruptions and partner protections among racial, ethnic, sex and gender diverse HIV serodifferent couples in the United States [PDF]

BMC Public Health, 2022
Background Most HIV cure-related studies involve interrupting antiretroviral treatment to assess the efficacy of pharmacologic interventions – also known as analytical treatment interruptions (ATIs).
Danielle M. Campbell, Karine Dubé, Portia D. Cowlings, Patricia Dionicio, Rowena M. Tam, Harsh Agarwal, Jamila K. Stockman, Judith D. Auerbach, John A. Sauceda, Amy A. Conroy, Mallory O. Johnson   +10 more
doaj   +2 more sources

The impact of magnitude and duration of plasma viremia during analytical treatment interruptions on CD4+ T cell recovery after ART resumption [PDF]

Journal of Virus Eradication
Objective: Analytical treatment interruption (ATI) is crucial for assessing the efficacy of HIV-1 cure strategies. Recent cure studies have implemented more flexible ART restart criteria, permitting higher plasma viral loads (pVLs) for longer periods ...
Vibeke Klastrup, Jesper Damsgaard Gunst, Ole Schmeltz Søgaard   +2 more
doaj   +2 more sources

Impact of analytical treatment interruptions on sexual behaviors: a mixed-methods longitudinal study of women enrolled in an HIV cure–related trial in Durban, South Africa [PDF]

HIV Research & Clinical Practice
Background Analytical treatment interruptions (ATIs) are increasingly used in HIV cure-related trials to assess intervention efficacy. Objective To assess the impact of participation in ATI-inclusive trials on sexual behaviors and transmission risks ...
Karine Dubé, Mzwakhe Wiseman Ngcobo, Ali Ahmed, Maryam Hussain, Ntombifuthi Langa, Ayanda Zulu, Luyanda Maphalala, Vanessa Pillay, Maud Mthembu, Fang Wan, Whitney Tran, Rachel Lau, Jamila K. Stockman, Thumbi Ndung’u, Krista L. Dong   +14 more
doaj   +2 more sources

‘It is scary to pause treatment’: perspectives on HIV cure-related research and analytical treatment interruptions from women diagnosed during acute HIV in Durban, South Africa: Socio-Behavioral research [PDF]

HIV Research & Clinical Practice
Background HIV remains a major challenge in KwaZulu-Natal, South Africa, particularly for young women who face disproportionate risks and barriers to prevention and treatment. Most HIV cure trials, however, occur in high-income countries.
Deli Mthimkhulu, Krista L. Dong, Mzwakhe Wiseman Ngcobo, Deborah Mindry, Ayanda Zulu, Ntombifuthi Langa, Luyanda Maphalala, Vanessa Pillay, Maud Mthembu, Annie Miall, Whitney Tran, Ana Dillen, Fang Wan, Ali Ahmed, Jamila K. Stockman, Maryam Hussain, Thumbi Ndung’u, Karine Dubé   +17 more
doaj   +2 more sources

The impact of analytical treatment interruptions and trial interventions on time to viral re‐suppression in people living with HIV restarting ART in cure‐related clinical studies: a systematic review and meta‐analysis [PDF]

Journal of the International AIDS Society
Introduction To assess the effectiveness of novel HIV curative strategies, “cure” trials require periods of closely monitored antiretroviral therapy (ART) analytical treatment interruptions (ATIs).
Ming Jie Lee, Miles Eason, Antonella Castagna, Galli Laura, Marie‐Angelique De Scheerder, James Riley, Pablo Tebas, Jesper Gunst, Ole Søgaard, Eric Florence, Eugene Kroon, Mark De Souza, Beatriz Mothe, Marina Caskey, Sarah Fidler   +14 more
doaj   +2 more sources