Results 21 to 30 of about 52,724 (260)

Evaluating the efficacy of therapeutic HIV vaccines through analytical treatment interruptions. [PDF]

J Int AIDS Soc, 2015
IntroductionThe development of an effective therapeutic HIV vaccine that induces immunologic control of viral replication, thereby eliminating or reducing the need for antiretroviral therapy (ART), would be of great value. Besides the obvious challenges of developing a therapeutic vaccine that would generate effective, sustained anti‐HIV immunity in ...
Graziani GM, Angel JB.
europepmc   +4 more sources

“This Is Actually a Really Unique Moment in Time”: Navigating Long-Acting HIV Treatment and HIV Cure Research with Analytical Treatment Interruptions—A Qualitative Interview Study in the United States [PDF]

AIDS Research and Human Retroviruses
Karine Dubé, Amaya G Perez-Brumer, Hursch Patel   +2 more
exaly   +2 more sources

Evaluating the psychosocial experiences of participants in HIV cure research before, during, and after analytical treatment interruptions: A longitudinal qualitative study in the United States [PDF]

Social Science and Medicine
Miranda Hill, Rebecca Hoh, Karine Dubé
exaly   +2 more sources

Analytical Treatment Interruption in HIV Trials: Statistical and Study Design Considerations [PDF]

Current HIV/AIDS Reports, 2021
Analytical treatment interruption (ATI) remains an essential component in clinical studies investigating novel agents or combination treatment strategies aiming to induce HIV treatment-free remission or long-term viral control. We provide an overview on key study design aspects of ATI trials from the perspective of statisticians.ATI trial designs have ...
Zheng, Lu, Tierney, Camlin, Bosch, Ronald J   +2 more
openaire   +2 more sources

“We Need to Deploy Them Very Thoughtfully and Carefully”: Perceptions of Analytical Treatment Interruptions in HIV Cure Research in the United States—A Qualitative Inquiry [PDF]

AIDS Research and Human Retroviruses, 2018
Karine Dubé, David Evans, Laurie Sylla
exaly   +2 more sources

Secondary HIV Infection and Mitigation in Cure-Related HIV Trials During Analytical Treatment Interruptions. [PDF]

J Infect Dis, 2019
To the Editor—We are writing to express concerns regarding facts reported in 2 recent Journal of Infectious Diseases articles pertaining to the ANRSLIGHT study, conducted in 18 clinical sites in France between September 2013 and May 2015. Initially, we were delighted to see the authors implemented several inclusion criteria that we believe were likely ...
Dee L, Boone CA, Palm D, Campbell D, Dubé K.   +4 more
europepmc   +4 more sources

The role of analytical treatment interruptions in shaping HIV-specific immunity and HIV cure. [PDF]

Curr Opin HIV AIDS
Purpose of review While existing guidance supports the use of analytical treatment interruptions (ATIs) in HIV cure clinical trials, their design must be tailored to the intervention and scientific question. As immunologically based cure strategies gain prominence, understanding how ATIs interact with HIV-specific immune ...
Weerasuria M, McMahon JH, Lewin SR, Lau JSY.   +3 more
europepmc   +3 more sources

Imaging and biopsy of HIV-infected individuals undergoing analytic treatment interruption

Frontiers in Medicine, 2022
BackgroundHIV persistence during antiretroviral therapy (ART) is the principal obstacle to cure. Lymphoid tissue is a compartment for HIV, but mechanisms of persistence during ART and viral rebound when ART is interrupted are inadequately understood.
Lau, Chuen-Yen, Adan, Matthew A., Earhart, Jessica, Seamon, Cassie, Nguyen, Thuy, Savramis, Ariana, Adams, Lindsey, Zipparo, Mary-Elizabeth, Madeen, Erin, Huik, Kristi, Grossman, Zehava, Chimukangara, Benjamin, Wulan, Wahyu Nawang, Millo, Corina, Nath, Avindra, Smith, Bryan R., Ortega-Villa, Ana M., Proschan, Michael, Wood, Bradford J., Hammoud, Dima A., Maldarelli, Frank   +20 more
openaire   +3 more sources

Impact of Analytical Treatment Interruption on Burden and Diversification of HIV Peripheral Reservoir: A Pilot Study [PDF]

Viruses, 2021
Background: If analytical antiretroviral-treatment (ART) interruption (ATI) might significantly impact quantitative or qualitative peripheral-total HIV-DNA is still debated. Methods: Six chronically HIV-1 infected patients enrolled in APACHE-study were analysed for peripheral-total HIV-DNA and residual viremia, major-resistance-mutations (MRMs) and C2 ...
Scutari, Rossana, Costabile, Valentino, Galli, Laura, Bellocchi, Maria Concetta, Carioti, Luca, Barbaliscia, Silvia, Poli, Andrea, Galli, Andrea, Perno, Carlo Federico, Santoro, Maria, Castagna, Antonella, Ceccherini Silberstein, Francesca, Alteri, Claudia, Spagnuolo, Vincenzo   +13 more
openaire   +6 more sources

‘With this study, we have hope that something is coming’: community members’ perceptions of HIV cure-related research in Durban, South Africa – a qualitative focus group study

HIV Research & Clinical Practice, 2023
Background Developing a cure for HIV remains a global scientific priority. In 2022, the Females Rising through Education, Support and Health (FRESH) cohort launched an HIV cure-related trial involving an analytical treatment interruption (ATI) in Durban,
Karine Dubé, Deli Mthimkhulu, Wiseman Ngcobo, Deborah Mindry, Luyanda Maphalala, Vanessa Pillay, Whitney Tran, Ana Korolkova, Thumbi Ndung’u, Krista Dong   +9 more
doaj   +1 more source