A partner protection package for HIV cure-related trials involving analytical treatment interruptions [PDF]
Lancet Infectious Diseases, The, 2023 Analytical treatment interruptions (ATIs) have become a key methodological approach to evaluate the effects of experimental HIV cure-related research interventions. During ATIs, sex partners of trial participants might be at risk of acquiring HIV. This risk raises both ethical and feasibility concerns about ATI trials.
Karine Dubé, Annette Rid
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Exploring Stigma and Self-Image: Mixed-Methods Insights from HIV Cure-Related Research Participants Undergoing Analytical Treatment Interruptions [PDF]
AIDS Patient Care and STDsThis mixed-methods study explored self-image among people with HIV participating in an HIV cure-related study involving analytical treatment interruptions (ATIs). Using both quantitative and qualitative approaches, we described how self-image emerged across study participation, focusing on internalized stigma, emotional strengths, and the psychosocial ...
Steven P Meanley +2 more
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HIV Research & Clinical Practice, 2023 Background A feature of HIV cure trials is the need to interrupt treatment to test the efficacy of experimental interventions—a process known as analytical treatment interruptions (ATIs).
Andrea Bilger +13 more
doaj +4 more sources
Impact of an analytical treatment interruption on partners and family members of trial participants in Durban, South Africa: a qualitative study [PDF]
Frontiers in Public HealthBackgroundHIV cure-related research often include analytical treatment interruptions (ATIs), which are monitored pauses in antiretroviral therapy (ART) to determine whether interventions can stimulate viral control without ART.
Krista L. Dong +19 more
doaj +2 more sources
Journal of Virus EradicationAnalytical treatment interruptions (ATIs) are widely used to evaluate HIV cure-related research interventions. However, sex partners of cure-related trial participants might be at risk of acquiring HIV during ATIs. Addressing this risk is key to ensuring
Karine Dubé +5 more
doaj +5 more sources
HIV Research & Clinical PracticeBackground There is limited systematic information available about the perspectives of participants enrolled in intensive combination HIV cure-related trials inclusive of an extended analytical treatment interruption (ATI).
Karine Dubé +5 more
doaj +5 more sources
Preliminary Acceptability of a Home-Based Peripheral Blood Collection Device for Viral Load Testing in the Context of Analytical Treatment Interruptions in HIV Cure Trials: Results from a Nationwide Survey in the United States [PDF]
Journal of Personalized Medicine, 2022 Karine Dubé +2 more
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How Unavoidable Are Analytical Treatment Interruptions in HIV Cure-Related Studies? [PDF]
J Infect Dis, 2019 Abstract In this discussion, 2 established researchers and clinical trialists debate their opposing views on the utility, benefits, and risks of the use of analytical interruption of antiretroviral therapy as a clinical trial end point and outcome measure in human studies seeking to induce remission of or eradicate human immunodeficiency
Margolis DM, Deeks SG.
europepmc +6 more sources
Perspectives on Analytical Treatment Interruptions in People Living with HIV and Their Health Care Providers in the Landscape of HIV Cure-Focused Studies [PDF]
AIDS Research and Human Retroviruses, 2020 Jillian Sy Lau +2 more
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Virological Outcome Measures During Analytical Treatment Interruptions in Chronic HIV-1-Infected Patients. [PDF]
Open Forum Infect Dis, 2019 Abstract Background Analytical treatment interruptions (ATI) are essential in research on HIV cure. However, the heterogeneity of virological outcome measures used in different trials hinders the interpretation of the efficacy of different strategies ...
Fehér C +12 more
europepmc +7 more sources