Results 41 to 50 of about 52,724 (260)

Residual Proviral Reservoirs: A High Risk for HIV Persistence and Driving Forces for Viral Rebound after Analytical Treatment Interruption [PDF]

Viruses, 2021
Antiretroviral therapy (ART) has dramatically suppressed human immunodeficiency virus (HIV) replication and become undetectable viremia. However, a small number of residual replication-competent HIV proviruses can still persist in a latent state even with lifelong ART, fueling viral rebound in HIV-infected patient subjects after treatment interruption.
Xiaolei Wang, Huanbin Xu
openaire   +3 more sources

Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms [PDF]

, 2014
Depression has been associated with drug consumption, including heavy or problematic cannabis use. According to an animal model of depression and substance use disorder comorbidity, we combined the olfactory bulbectomy (OBX) model of depression with ...
Amchova P, Babinska Z, Dusek L, FADDA, PAOLA, Fattore L., FRATTA, WALTER, Giugliano V, Kucerova J, Micale V, SCHERMA, MARIA, Sulcova A, ZANDA, MARY TRESA   +11 more
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Characterization of intact proviruses in blood and lymph node from HIV-infected individuals undergoing analytical treatment interruption [PDF]

Journal of Virology, 2018
AbstractThe role of lymphoid tissue as a potential source of HIV-1 rebound following interruption of antiretroviral therapy is uncertain. To address this issue, we compared the latent viruses obtained from CD4+ T cells in peripheral blood and lymph nodes to viruses emerging during treatment interruption.
Vibholm, Line K., Lorenzi, Julio C.C., Pai, Joy A., Cohen, Yehuda Z., Oliveira, Thiago Y., Barton, John P., Noceda, Marco Garcia, Lu, Ching-Lan, Ablanedo-Terrazas, Yuria, Del Rio Estrada, Perla M., Teran, Gustavo Reyes, Tolstrup, Martin, Denton, Paul W., Damsgaard, Tine, Søgaard, Ole S., Nussenzweig, Michel C.   +15 more
openaire   +5 more sources

Species sensitivity of zeolite minerals for uptake of mercury solutes [PDF]

, 2006
The uptake of inorganic Hg2+ and organometallic CH3Hg+ from aqueous solutions by 11 different natural zeolites has been investigated using a batch distribution coefficient (Kd) method and supported by a preliminary voltammetric study.
A. Chimedtsogzol, A. Dyer, Boudou, Campbell, Cotton, Fergusson, Garcia, L. S. Campbell, Meier, Meyer, Rice, Sersen, Tsitsishvili, Weitkamp   +13 more
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Kinetics of plasma cytokines and chemokines during primary HIV‐1 infection and after analytical treatment interruption [PDF]

HIV Medicine, 2009
BackgroundThere are strong theoretical arguments for initiating antiretroviral therapy (ART) during primary HIV‐1 infection (PHI) to preserve HIV‐1‐specific T‐cell responses and to decrease immune activation.MethodsWe assessed the degree of immune activation during PHI and after analytical treatment interruption (ATI) in plasma samples from 22 subjects
B, Barqasho, P, Nowak, A, Tjernlund, S, Kinloch, L-E, Goh, F, Lampe, M, Fisher, J, Andersson, A, Sönnerborg   +8 more
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Characterization of Physicians That Might Be Reluctant to Propose HIV Cure-Related Clinical Trials with Treatment Interruption to Their Patients? The ANRS-APSEC Study

Vaccines, 2020
HIV cure-related clinical trials (HCRCT) with analytical antiretroviral treatment interruptions (ATIs) have become unavoidable. However, the limited benefits for participants and the risk of HIV transmission during ATI might negatively impact physicians’
Christel Protiere, Lisa Fressard, Marion Mora, Laurence Meyer, Marie Préau, Marie Suzan-Monti, Jean-Daniel Lelièvre, Olivier Lambotte, Bruno Spire, the APSEC Study Group   +9 more
doaj   +1 more source

Ethics of HIV cure research: an unfinished agenda

BMC Medical Ethics, 2021
Background The pursuit of a cure for HIV is a high priority for researchers, funding agencies, governments and people living with HIV (PLWH). To date, over 250 biomedical studies worldwide are or have been related to discovering a safe, effective, and ...
Karine Dubé, John Kanazawa, Jeff Taylor, Lynda Dee, Nora Jones, Christopher Roebuck, Laurie Sylla, Michael Louella, Jan Kosmyna, David Kelly, Orbit Clanton, David Palm, Danielle M. Campbell, Morénike Giwa Onaiwu, Hursch Patel, Samuel Ndukwe, Laney Henley, Mallory O. Johnson, Parya Saberi, Brandon Brown, John A. Sauceda, Jeremy Sugarman   +21 more
doaj   +1 more source

A minor population of macrophage-tropic HIV-1 variants is identified in recrudescing viremia following analytic treatment interruption [PDF]

Proceedings of the National Academy of Sciences, 2020
HIV-1 persists in cellular reservoirs that can reignite viremia if antiretroviral therapy (ART) is interrupted. Therefore, insight into the nature of those reservoirs may be revealed from the composition of recrudescing viremia following treatment cessation.
Viviane M. Andrade, Carla Mavian, Dunja Babic, Thaissa Cordeiro, Mark Sharkey, Labelle Barrios, Christian Brander, Javier Martinez-Picado, Judith Dalmau, Anuska Llano, Jonathan Z. Li, Jeffrey Jacobson, Christy L. Lavine, Michael S. Seaman, Marco Salemi, Mario Stevenson   +15 more
openaire   +3 more sources

Professional self-regulation in a changing architecture of governance: comparing health policy in the UK and Germany [PDF]

, 2008
This chapter compares transformations in professional self-regulation in the UK and Germany through the lens of governance. We introduce an expanded concept of governance that includes national configurations of state–profession relationships and places
Allsop, Judith, Kuhlmann, Ellen
core   +1 more source

Acceptability, motivation and the prospect of cure for people living with HIV and their healthcare providers in HIV cure-focused treatment interruption studies

AIDS Research and Therapy, 2020
Background Analytical treatment interruptions (ATI) are commonly used clinical endpoints to assess interventions aimed at curing HIV or achieving antiretroviral therapy (ART)-free HIV remission.
Jillian S. Y. Lau, Miranda Z. Smith, Brent Allan, Cipriano Martinez, Jennifer Power, Sharon R. Lewin, James H. McMahon   +6 more
doaj   +1 more source