Results 31 to 40 of about 52,724 (260)

Community HIV clinicians’ perceptions about HIV cure-related research in the Northwestern United States

HIV Research & Clinical Practice, 2022
Background: Research on stakeholder perspectives of HIV cure research has involved people with HIV (PWH), who generally cite the importance of HIV clinician advice in making decisions about trial participation.
Laurie Sylla, Hursch Patel, Michael Louella, Jane Simoni, Karine Dubé   +4 more
doaj   +1 more source

A landscape analysis of HIV cure-related clinical research in 2019

Journal of Virus Eradication, 2020
Objectives: In 2018, we surveyed investigators conducting HIV cure-related clinical research, drawing on information from the online listing established by Treatment Action Group (TAG).
Liz Barr, Richard Jefferys
doaj   +1 more source

Extensive characterization of HIV-1 reservoirs reveals links to plasma viremia before and during analytical treatment interruption [PDF]

Cell Reports, 2021
SummaryThe HIV-1 reservoir is composed of cells harboring latent proviruses that are capable of contributing to viremia upon antiretroviral treatment (ART)interruption. Although this reservoir is known to be maintained by clonal expansion, the contribution of large, infected cell clones to residual viremia and viral rebound remains underexplored. Here,
Cole, Basiel, Lambrechts, Laurens, Boyer, Zoe, Noppe, Ytse, De Scheerder, Marie-Angelique, Eden, John-Sebastian, Vrancken, Bram, Schlub, Timothy E., McLaughlin, Sherry, Frenkel, Lisa M., Palmer, Sarah, Vandekerckhove, Linos   +11 more
openaire   +4 more sources

Elastic calls in an integrated services network: the greater the call size variability the better the QoS [PDF]

, 2002
We study a telecommunications network integrating prioritized stream calls and delay tolerant elastic calls that are served with the remaining (varying) service capacity according to a processor sharing discipline. The remarkable observation is presented
Boucherie, R.J., Litjens, R.
core   +10 more sources

A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption

Journal of Virus Eradication, 2020
Analytic treatment interruptions (ATIs) are currently the standard for assessing the impact of experimental interventions aimed at inducing sustained antiretroviral therapy (ART)-free remission in trials related to HIV cure. ATIs are associated with substantial risk to both study participants and their sexual partner(s).
Peluso, Michael J, Dee, Lynda, Campbell, Danielle, Taylor, Jeff, Hoh, Rebecca, Rutishauser, Rachel L, Sauceda, John, Deeks, Steven G, Dubé, Karine   +8 more
openaire   +5 more sources

Multiple imputation approach for interval-censored time to HIV RNA viral rebound within a mixed effects Cox model [PDF]

, 2018
This is the peer reviewed version of the following article: “Alarcón-Soto, Y, Langohr K., Fehér, C., García, F., and Gómez, G. (2018) Multiple imputation approach for interval-censored time to HIV RNA viral rebound within a mixed effects Cox Model ...
Alarcón Soto, Yovaninna, Fehér, C., García Alcaide, Felipe, Gómez Melis, Guadalupe, Langohr, Klaus   +4 more
core   +2 more sources

Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques

Retrovirology, 2023
A biologically relevant non-human primate (NHP) model of HIV persistence in the central nervous system (CNS) is necessary. Most current NHP/SIV models of HIV infection fail to recapitulate viral persistence in the CNS without encephalitis or fail to ...
Rachel M. Podgorski, Jake A. Robinson, Mandy D. Smith, Suvadip Mallick, Huaqing Zhao, Ronald S. Veazey, Dennis L. Kolson, Katharine J. Bar, Tricia H. Burdo   +8 more
doaj   +1 more source

Recommendations for analytical antiretroviral treatment interruptions in HIV research trials—report of a consensus meeting

The Lancet HIV, 2019
Analytical antiretroviral treatment interruption (ATI) is an important feature of HIV research, seeking to achieve sustained viral suppression in the absence of antiretroviral therapy (ART) when the goal is to measure effects of novel therapeutic interventions on time to viral load rebound or altered viral setpoint.
Julg, Boris, Dee, Lynda, Ananworanich, Jintanat, Barouch, Dan H, Bar, Katharine, Caskey, Marina, Colby, Donn J, Dawson, Liza, Dong, Krista L, Dubé, Karine, Eron, Joseph, Frater, John, Gandhi, Rajesh T, Geleziunas, Romas, Goulder, Philip, Hanna, George J, Jefferys, Richard, Johnston, Rowena, Kuritzkes, Daniel, Li, Jonathan Z, Likhitwonnawut, Udom, van Lunzen, Jan, Martinez-Picado, Javier, Miller, Veronica, Montaner, Luis J, Nixon, Douglas F, Palm, David, Pantaleo, Giuseppe, Peay, Holly, Persaud, Deborah, Salzwedel, Jessica, Salzwedel, Karl, Schacker, Timothy, Sheikh, Virginia, Søgaard, Ole S, Spudich, Serena, Stephenson, Kathryn, Sugarman, Jeremy, Taylor, Jeff, Tebas, Pablo, Tiemessen, Caroline T, Tressler, Randall, Weiss, Carol D, Zheng, Lu, Robb, Merlin L, Michael, Nelson L, Mellors, John W, Deeks, Steven G, Walker, Bruce D   +48 more
openaire   +7 more sources

Label-free electrochemical monitoring of DNA ligase activity [PDF]

, 2008
This study presents a simple, label-free electrochemical technique for the monitoring of DNA ligase activity. DNA ligases are enzymes that catalyze joining of breaks in the backbone of DNA and are of significant scientific interest due to their essential
Ahel I., Bellamy S. R., Borodina T. A., Bullard D. R., Cahova-Kucharikova K., Cao W. G., Doherty A. J., Fadrna R., Fojta M., Fojta M., Fojta M., Fojta M., Fojta M., Fojta M., Friedberg E. C., Gowers D. M., Heiter D. F., Kucharikova K., Liu L. F., Palecek E., Pascal J. M., Rass U., Schrock R. D., Scott B. O. S., Shuman S., Tomkinson A. E., Vacek J., Wilkinson A., Wilkinson A., Zauner G.   +29 more
core   +1 more source

Attitudes About Analytic Treatment Interruption (ATI) in HIV Remission Trials with Different Antiretroviral Therapy (ART) Resumption Criteria

AIDS and Behavior, 2022
HIV remission trials often require temporary stopping of antiretroviral therapy (ART)—an approach called analytic treatment interruption (ATI). Trial designs resulting in viremia raise risks for participants and sexual partners. We conducted a survey on attitudes about remission trials, comparing ART resumption criteria (lower-risk “time to rebound ...
Sacdalan, Carlo, Cadigan, R. Jean, Ormsby, Nuchanart, Prueksakaew, Peeriya, Rennie, Stuart, Isaacson, Sinéad C., Benjapornpong, Khunthalee, Vasan, Sandhya, Kroon, Eugène, Colby, Donn J., Ananworanich, Jintanat, Peay, Holly L., Gwaltney, Angela, Henderson, Gail E., Jupimai, Thidarat, Phanuphak, Nittaya   +15 more
openaire   +3 more sources