Results 61 to 70 of about 52,724 (260)

Antiretroviral Drug-Resistance Mutations on the Gag Gene: Mutation Dynamics during Analytic Treatment Interruption among Individuals Experiencing Virologic Failure

Pathogens, 2022
We describe drug-resistance mutation dynamics of the gag gene among individuals under antiretroviral virologic failure who underwent analytical treatment interruption (ATI). These mutations occur in and around the cleavage sites that form the particles that become the mature HIV-1 virus.
James R. Hunter, Domingos E. Matos dos Santos, Patricia Munerato, Luiz Mario Janini, Adauto Castelo, Maria Cecilia Sucupira, Hong-Ha M. Truong, Ricardo Sobhie Diaz   +7 more
openaire   +3 more sources

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Antibody Responses After Analytic Treatment Interruption in Human Immunodeficiency Virus-1-Infected Individuals on Early Initiated Antiretroviral Therapy [PDF]

Open Forum Infectious Diseases, 2016
Abstract The examination of antibody responses in human immunodeficiency virus (HIV)-1-infected individuals in the setting of antiretroviral treatment (ART) interruption can provide insight into the evolution of antibody responses during viral rebound.
Stephenson, Kathryn, Bricault, Christine, Seaman, Michael, Rosenberg, Eric, Barouch, Dan, Neubauer, George H., Shields, Jennifer, Bayne, Madeleine, Reimer, Ulf, Pawlowski, Nikolaus, Knaute, Tobias, Zerweck, Johannes   +11 more
openaire   +3 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

(Re)conceptualising physical activity participation as career [PDF]

, 2019
Physical activity is increasingly positioned as playing an important role in preventing and mitigating many of the decrements associated with biological ageing.
Alexander, Becker, Boltanski, Bourdieu, Bourdieu, Braude, Eichberg, Emmanuelle Tulle, Foster, Guell, Heidegger, Hénaff-Pineau, James Bowness, McHugh, Prus, Silverman, Spirduso, Stevenson, Stevenson, Victoria J. Palmer   +19 more
core   +3 more sources

Circulating CD30+CD4+ T Cells Increase Before Human Immunodeficiency Virus Rebound After Analytical Antiretroviral Treatment Interruption

The Journal of Infectious Diseases, 2019
AbstractBackgroundIdentification of nonviral markers of human immunodeficiency virus (HIV) infection that increase before viral rebound during analytical treatment interruption (ATI) may affect HIV persistence research. We previously showed that HIV ribonucleic acid (RNA) is enriched in CD30+CD4+ T cells in many individuals.
Prator, Cecilia A, Thanh, Cassandra, Kumar, Shreya, Pan, Tony, Peluso, Michael J, Bosch, Ronald, Jones, Norman, Milush, Jeffrey M, Bakkour, Sonia, Stone, Mars, Busch, Michael P, Deeks, Steven G, Hunt, Peter W, Henrich, Timothy J   +13 more
openaire   +5 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Rapid viral rebound after analytical treatment interruption in patients with very small HIV reservoir and minimal on‐going viral transcription [PDF]

Journal of the International AIDS Society, 2020
AbstractIntroductionViral remission after analytical treatment interruption (ATI), termed post‐treatment control, has been described in a small proportion of HIV‐positive patients. This phenomenon has been separately associated to both low levels of HIV‐1 proviral DNA as well as cell‐associated RNA.
Pieter Pannus, Sofie Rutsaert, Stéphane De Wit, Sabine D Allard, Guido Vanham, Basiel Cole, Coca Nescoi, Joeri Aerts, Ward De Spiegelaere, Achilleas Tsoumanis, Marie‐Madeleine Couttenye, Natacha Herssens, Marie‐Angélique De Scheerder, Linos Vandekerckhove, Eric Florence   +14 more
openaire   +5 more sources

Transport and reduction of nitrate in clayey till underneath forest and arable land. [PDF]

, 2004
Transport and reduction of nitrate in a typically macroporous clayey till were examined at variable flow rate and nitrate flux. The experiments were carried out using saturated, large diameter (0.5 m), undisturbed soil columns (LUC), from a forest and ...
Eiland, F., Helstrup, T., Jensen, M.B., Jørgensen, P.R., Urup, J., Vinther, F.P.   +5 more
core   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source