Results 71 to 80 of about 52,724 (260)

Lack of Detectable HIV-1 Molecular Evolution during Suppressive Antiretroviral Therapy [PDF]

, 2014
A better understanding of changes in HIV-1 population genetics with combination antiretroviral therapy (cART) is critical for designing eradication strategies.
Angeline O'Shea, AS Perelson, B Joos, B Shi, C Shiu, Carry Poethke, Catherine Rehm, D McMahon, E Martinez, Elizabeth M. Anderson, F Maldarelli, F Maldarelli, Frank Maldarelli, G Achaz, H Hatano, H Mens, HF Gunthard, IM Rouzine, JB Dinoso, JM Benito, JM Coffin, JM Coffin, JM Cornuet, JM Llibre, John M. Coffin, John W. Mellors, Jonathan Spindler, JR Bailey, JW Cohen Stuart, K Tamura, L Ruiz, M Kearney, M Kearney, MA Martinez, MA Polis, Mary F. Kearney, MJ Buzon, N Llewellyn, Nicholas Kovacs, Q Zhang, RE Nettles, Robert F. Siliciano, RR Hudson, RT Gandhi, S Palmer, S Palmer, SA Yukl, Sloane Yu, T Elbeik, TA Wagner, TP Brennan, TW Chun, TW Chun, Wei Shao   +53 more
core   +3 more sources

Early Viral Dynamics Predict Human Immunodeficiency Virus Posttreatment Control After Analytic Treatment Interruption

The Journal of Infectious Diseases
Abstract Background A key research priority for developing a human immunodeficiency virus (HIV) cure strategy is to define the viral dynamics and biomarkers associated with sustained posttreatment control.
Gesham Magombedze, Elena Vendrame, Devi SenGupta, Romas Geleziunas, Susan Little, Davey Smith, Bruce Walker, Jean-Pierre Routy, Frederick M Hecht, Tae-Wook Chun, Michael Sneller, Jonathan Z Li, Steven G Deeks, Michael J Peluso   +13 more
openaire   +3 more sources

Initiation of Antiretroviral Therapy during Primary HIV Infection: Effects on the Latent HIV Reservoir, Including on Analytic Treatment Interruptions

Aids Reviews, 2021
Antiretroviral therapy (ART) inhibits HIV replication but does not eradicate the latent reservoir. The previous research suggests that earlier ART initiation provides benefit on limiting reservoir size, but timing and extent of this effect remain unclear.
Eva M, Shelton, Daniel B, Reeves, Rachel A, Bender Ignacio   +2 more
openaire   +3 more sources

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash, Anis Rabbani Nourani, A. K. M. Fazlur Rahman, Dima Ezmigna, Tarig Ali‐Dinar   +4 more
wiley   +1 more source

Moving on - beyond lean thinking [PDF]

, 2004
Lean Thinking is currently often positioned as the underlying theory of lean production among practitioners and academics, although its originators, Womack and Jones, seem not to have presented it as a theory.
Koskela, LJ
core   +1 more source

The CAST Time Projection Chamber [PDF]

, 2007
One of the three X-ray detectors of the CAST experiment searching for solar axions is a Time Projection Chamber (TPC) with a multi-wire proportional counter (MWPC) as a readout structure.
A Ortiz, A Placci, A Rodrigurez, Abbon P, Andriamonje S, Andriamonje S, B Beltrán, B Lakić, D Autiero, Dumont G, E Chesi, F Formenti, G Luzón, H Gómez, I G Irastorza, J A Villar, J M Carmona, J Morales, J Ruz, K Zioutas, Kuster M, L Di Lella, L Musa, M Davenport, M Delattre, M Hasinoff, Musa L, Ruz J Luzón G, S Cebrián   +28 more
core   +3 more sources

Prevalence and Trajectory of Household Material Hardship Among Children With Advanced Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Families of children with advanced cancer living in poverty experience inferior outcomes including poor parent mental health and worse child quality of life. Household material hardship (HMH: food, housing, transportation, and/or utility insecurity) is a modifiable poverty exposure—and potential intervention target—that ...
Sarah Wright, Morgan A. Paul, Selena Murcia Mendez, Emily Jones, Lucille Lokko, Chelsea Heneghan, Nicholas Purol, Morgan Arnold, Rahela Aziz‐Bose, Colleen A. Kelly, Sandi L. Pruitt, Joanne Wolfe, Kira Bona, Puja J. Umaretiya   +13 more
wiley   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source