Results 161 to 170 of about 67,524,308 (281)

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Closing the Feedback Loop: Improving Communication of Findings With Aboriginal Research Participants Through Participatory Action Research. [PDF]

Health Expect
Smith S, Harris T, Savietto K, Robinson M, Pearson G, Paull S, Anderson YC.   +6 more
europepmc   +1 more source

Intuition and congruence: researching peace in Melanesia

, 2011
Researching peace and conflict in the Solomon Islands is a sensitive and nuanced process. The research must be guided by a methodology that is congruent with the epistemology and ontology of the Melanesian context, the peace studies discipline, as well ...
Vella, Louise
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Co-designing interventions for chronic pain: A participatory action research study with south Asian women. [PDF]

Br J Health Psychol
Biring S, Burton AE, Kevern P.
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Development of a participatory action research-based intervention to enhance infection prevention and antimicrobial stewardship among European nursing home staff. [PDF]

JAC Antimicrob Resist
Theut M, Lykkegaard J, Antsupova V, Hansen MP, Marloth T, Llor C, Garcia-Sangenis A, Monfà R, Moragas A, Anastasaki M, Tsoulchai G, Lionis C, Sodja N, Petek D, Benko R, Balint A, Kowalczyk A, Jaruseviciene L, Glasova H, Glasa J, Jensen JN.   +20 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Empowering health service providers in health center in low- and middle-income countries: results of a participatory action research study in Iran. [PDF]

BMC Health Serv Res
Jahromi MK, Vizeshfar F, Torabizadeh C, Yektatalab S.   +3 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source