Results 91 to 100 of about 441,738 (307)

Culture, participative decision making and job satisfaction [PDF]

open access: yes
This study explores the impact of culture on participative decision making (PDM) and job satisfaction (JS) using data obtained from the European Values Study.
De Wet van der Westhuizen   +2 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Modern ‘live’ football: moving from the panoptican gaze to the performative, virtual and carnivalesque [PDF]

open access: yes, 2012
Drawing on Redhead's discussion of Baudrillard as a theorist of hyperreality, the paper considers the different ways in which the mediatized ‘live’ football spectacle is often modelled on the ‘live’ however eventually usurps the ‘live’ forms position in ...
Anderson B.   +24 more
core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Towards a more participatory style of election campaigning: identifying the comparative use of Web 2.0 by parties and candidates in elections 2007-2010 [PDF]

open access: yes
Election campaigning tends to be synonymous with top-down, persuasive and propaganda-style communication; with the strategic aim being to win the support of voters crucial for the victory, either in local or national contests, of a candidate or party ...
Jackson, Nigel   +2 more
core  

Los Angeles County Arts Commission: Public Engagement in the Arts - A Review of Recent Literature [PDF]

open access: yes, 2016
Do all Americans have equal access to the arts? Are the arts accessible and inclusive for all communities? National rates of arts participation as measured by attendance at live benchmark events have been trending down for the past few decades ...
Bronwyn Mauldin, Stephanie N. Stallings
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Participatory Culture in Indonesian Communities: A Study of #Gerakbersama Campaign

open access: yesHumaniora, 2018
The research aimed to provide an overview on how digital conversation and participatory culture processes take place in Indonesian communities in #GerakBersama campaign. This research used a qualitative approach with case study methods.
Mia Angeline, Yuanita Safitri
doaj   +1 more source

Participatory Art Methods in Practice: An Artist’s Tentative Steps into Field Research [PDF]

open access: yes, 2012
This project aimed to examine if community projects can have a positive impact on art jewellery practice. This was done through the development of a community project with a group of Irish Traveller women, in collaboration with Brent Irish Advisory ...
Bradshaw-Heap, Laura
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

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