Results 101 to 110 of about 445,655 (303)
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Participatory design and participatory development: a comparative review [PDF]
, 2008 This paper examines literature in the twin domains of participatory interactive systems design and participatory approaches to international development.
Dearden, Andy, Rizvi, H.
core +2 more sources
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
“No Geek Girls”: Boundary-Work and Gendered Identity in the Israeli Geek Community
International Journal of Communication, 2022 Boundary-work theory describes the discursive efforts of groups to limit access to membership and collective symbolic capital. In this article, we explore the gendered nature of boundary-work within an online community of Geeks—a subcultural identity ...
Hadas Gur-Ze'ev, Neta Kligler-Vilenchik
doaj
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Troubling futures: can participatory design research provide a generative anthropology for the 21st century? [PDF]
, 2015 This essay argues there is value in considering participatory design as a form of generative anthropology at a time when we recognise that we need not only to understand cultures but to change them towards sustainable living.
Light, Ann
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Global StorytellingAlthough fan cultures highlighting active audience engagement is prevalent in East Asia, the process and impact of such engagement have not been thoroughly explored in the literature.
BU Jiahua
doaj +2 more sources
The Digital Cultural Atlas Project: Design Research and Cultural Narratives. An Experiential Approach for Design Education. [PDF]
, 2008 This paper outlines an approach developed for teaching research methods in a graphic design program, working in an interdisciplinary context with cultural researchers. Initially, the Digital Cultural Atlas (DCA) is introduced, as a 'work-in-progress' web
Shumack, Kaye
core