Results 91 to 100 of about 4,314,651 (296)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

New Media Literacy Education for Children in the Context of Participatory Culture: Deficiency and Construction [PDF]

, 2015
Rapid development of new media has given birth to the so-called participatory culture. However, as an active group, children are swept along in this trend and moreover, they are thrown to the edge of danger of over-entertainment and over-consumption ...
YIN, Guoqiang, Zhou, Anping
core   +1 more source

Packaging Hashtags; Understanding Participatory Culture

, 2017
Packaging Hashtags for (re)Composition: Rhetorical Velocity and Topoii in the Invention of Hashtags (Nicholas DeArmas) Understanding Participatory Culture through Hashtag Activism After the Orlando Pulse Tragedy (Nicholas DeArmas, Wendy Givoglu, Jennifer
Miller, Jennifer, Moran, David, Vie, Stephanie, Givoglu, Wendy, DeArmas, Nicholas   +4 more
core  

Making media participatory

, 2015
In 2002, Media International Australia published a special issue on Citizens' Media (no. 103). It profiled new academic work that was reinvigorating research into alternative and community-interest media.
Spurgeon, Christina L., Edmond, Maura
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Participatory plant breeding and property rights

, 2017
Participatory plant-breeding (PPB) efforts have proliferated within the last 10 years; however, other key aspects have yet to be explored, As in many other fields, the property rights and ethical issues of participatory plant breeding are lagging far ...
CGIAR Systemwide Program on Participatory Research and Gender Analysis for Technology Development and Institutional Innovation
core   +1 more source

A Participatory Perspective on Cross-Cultural Design [PDF]

, 2014
Designers face a number of challenges in terms of how to design interactive systems with indigenous groups. Every layer of development faces obstacles from designing localized interfaces to facilitating prototype evaluations in the wild. This article argues for the importance of continuous user involvement and participatory design.
openaire   +2 more sources