Results 61 to 70 of about 445,655 (303)

Participatory Design for Cultural Representation: A Cultural Transparency Perspective [PDF]

, 2013
Participatory design approaches are being increasingly employed for designing digital artefacts and information systems with and for local communities. These cases require a reconceptualization of PD processes to account for widened knowledge gaps between designers and community members, and new patterns of community-defined design goals. In this paper
Amalia G. Sabiescu, Nemanja Memarovic
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

New Media and Youth Political Action [PDF]

, 2012
To rigorously consider the impact of new media on the political and civic behavior of young people, The MacArthur Research Network on Youth and Participatory Politics (YPP) developed and fielded one of the first large-scale, nationally representative ...
Benjamin Bowyer, Cathy Cohen, Ellen Middaugh, Jon Rogowski, Joseph Kahne   +4 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Restricting Diversity to Promote Democracy: Community Literacies and Playing Across Spaces

Cultural Science, 2019
In 2018 a teacher in a Montessori school captured on camera two children in her special education classroom using a touchscreen tablet to interact. To her it was significant: these pre-verbal children had found a way to independently share aspects of ...
Owen Samantha
doaj   +1 more source

National Forest Programmes in Europe: Generating policy-relevant propositions for formulation and implementation [PDF]

, 2004
The COST Action E19 on National Forest Programmes in a European Context assembled more than 70 researchers and civil servants from 20 European countries and the USA. Some meetings were also attended by scholars from Canada, China and Japan.
Humphreys, David
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A New Consumerism: The influence of social technologies on product design [PDF]

, 2014
Social media has enabled a new style of consumerism. Consumers are no longer passive recipients; instead they are assuming active and participatory roles in product design and production, facilitated by interaction and collaboration in virtual ...
de Vere, I
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

"Television 2.0: Viewer and fan engagement with digital TV," by Rhiannon Bury

Transformative Works and Cultures, 2019
Review of Rhiannon Bury. Television 2.0: Viewer and Fan Engagement with Digital TV. New York: Peter Lang, 2017, paperback, $48 (147p) ISBN 978-1-4331-3852-2.
Bridget Kies
doaj   +1 more source