Results 41 to 50 of about 31,582 (258)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

On the imaginaries surrounding participatory digital tools in museums

open access: yesHybrid, 2022
This paper proposes to question a participatory digital project aimed at enhancing the culture of the community of gypsy women in Arles, through the analysis of the web documentary: Gypsy women of the plane tree quay, set up by the Museon Arlaten, the ...
Eva Sandri
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Making time for storytelling; the challenges of community building and activism in a rural locale

open access: yesSeminar.net, 2010
The uneven projection of voices from or within a community can be addressed, in part, by methods such as digital storytelling in a technology and media-savvy society.
Sarah Copeland, Clodagh Miskelly
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Unveiling the War and Constructing Identities: Exploring Memes in Ukrainian and Russian Social Media during the Russian Invasion of Ukraine

open access: yesCzech Journal of International Relations
The article examines the generation and deployment of visual narratives in Ukrainian and Russian digital participatory cultures, with a specific focus on internet memes in the context of the Russian invasion of Ukraine. It analyzes the form, content, and
ALINA MOZOLEVSKA
doaj   +1 more source

Speed Detection, intertextuality and audiences in Sherlock

open access: yesMise au Point, 2017
In its English context, Sherlock was a huge success when broadcast on BBC One. The series, however, soon also became the center of a massive, creative, mostly online-based fan attention.
Asta Koch, Palle Schantz Lauridsen
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Community Media 2.0: A Report from the ‘Co-Creative Communities’ Forum

open access: yesCultural Science, 2013
Participatory digital culture presents major challenges to all traditional media outlets, but it presents very direct challenges to the community broadcast sector, which was established from the outset as local, community-driven and participatory.
Edmond Maura
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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