Results 41 to 50 of about 4,146,137 (251)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Making time for storytelling; the challenges of community building and activism in a rural locale

open access: yesSeminar.net, 2010
The uneven projection of voices from or within a community can be addressed, in part, by methods such as digital storytelling in a technology and media-savvy society.
Sarah Copeland, Clodagh Miskelly
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Unveiling the War and Constructing Identities: Exploring Memes in Ukrainian and Russian Social Media during the Russian Invasion of Ukraine

open access: yesCzech Journal of International Relations
The article examines the generation and deployment of visual narratives in Ukrainian and Russian digital participatory cultures, with a specific focus on internet memes in the context of the Russian invasion of Ukraine. It analyzes the form, content, and
ALINA MOZOLEVSKA
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

'Thinking-through-Complicity' with Te Iwi o Ngāti Hauiti: Towards a Critical Use of Participatory Video for Research [PDF]

open access: yes, 2012
This thesis explores some of the seductions and dangers of participatory video for research (PVR) involving Indigenous Māori and Pākehā research partners.
Kindon, Sara Louise
core  

Speed Detection, intertextuality and audiences in Sherlock

open access: yesMise au Point, 2017
In its English context, Sherlock was a huge success when broadcast on BBC One. The series, however, soon also became the center of a massive, creative, mostly online-based fan attention.
Asta Koch, Palle Schantz Lauridsen
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Participatory video production: An ideal or wishful thinking [PDF]

open access: yes, 2010
In 2003 participatory video productions were undertaken in Tanzania to support the work of the World Bank under the aegis of the Economic and Social Research Foundation in Tanzania (ESRF).
Mhando, M.
core  

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