Results 121 to 130 of about 551,295 (306)

Revisiting the origins of participatory design. A review from the south

ARQUISUR Revista
Participatory design addresses the project activity from a multiactoral and inclusive approach. Focusing on design, this article specifically reconstructs the history of a participatory approach to architectural design.
Juan Santiago Palero
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Use of an interdisciplinary, participatory design approach to develop a usable patient self-assessment tool in atrial fibrillation

Patient Preference and Adherence, 2013
Lori MacCallum,1,2 Heather McGaw,1 Nazanin Meshkat,3 Alissia Valentinis,4 Leslie Beard Ashley,5 Rajan Sacha Bhatia,3,6,7 Kaye Benson,7 Noah Ivers,6,8 Kori Leblanc,2,7 Dante Morra3,5,7 1Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto ...
MacCallum L, McGaw H, Meshkat N, Valentinis A, Beard Ashley L, Bhatia RS, Benson K, Ivers N, Leblanc K, Morra D   +9 more
doaj  

Getting Closer, Empathising and Understanding: Setting the Stage for a Co-design Project with People with Dementia [PDF]

Interaction Design and Architecture(s), 2015
This paper discusses the initial work of a doctoral research project that explores how communication design can enable people with dementia and their social circle to codesign strategies to communicate.
Rita Maldonado Branco, Joana Quental, Óscar Ribeiro   +2 more
doaj  

UbiComp in Opportunity Spaces: Challenges for Participatory Design

, 2006
The rise of ubiquitous computing (UbiComp), where pervasive, wireless and disappearing technologies offer hitherto unavailable means of supporting activity, increasingly opens up ‘opportunity spaces’.
Cruickshank, Don G., De Roure, David C., Fitzpatrick, Geraldine, Halloran, John, Hornecker, Eva, Michaelides, Danius T., Millard, David E., Weal, Mark J.   +7 more
core   +1 more source

Toward Digital, Critical, Participatory Action Research: Lessons From The #BarrioEdProj [PDF]

, 2014
The Education in our Barrios project, or #BarrioEdProj, is a digital critical participatory action research (D+CPAR) project that examines the interconnected remaking of public education and a New York City Latino core community in an era of racial ...
Mayorga, Edwin
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Participatory Data Analysis: A New Method for Investigating Human Energy Practices [PDF]

, 2014
This paper presents a novel data-driven method to investigate the interdependence between technology design and human energy practices. The method – called Participatory Data – makes use of fine-grained energy data collected via smart meters and smart ...
Bourgeois, Jacky, Kortuem, Gerd, Price, Blaine, van der Linden, Janet   +3 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source