Results 141 to 150 of about 551,295 (306)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Value of Design-led Innovation in Chinese SMEs [PDF]

, 2009
Organised by: Cranfield UniversityThis paper focuses on understanding the role and use of design-led innovation in Chinese SMEs. The insights were gained by undertaking a pilot study, based on an applied developmental research approach involving ...
Bolton, S.
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Behind the scenes of a crowdmapping tool design and implementation : guidelines for participatory mapping practices in a multicultural environment

Geographia Polonica
This study addresses the gap in knowledge regarding effective design practices for crowdmapping in participatory mapping, considering the diverse agendas, expectations, and needs of stakeholders. Through interviews and analysis of a crowdmapping project,
Michal Rzeszewski, Patryk Kaczmarek, Piotr Lupa, Tomasz Herodowicz, Katarzyna Fagiewicz, Joanna Morawska, Paweł Churski   +6 more
doaj   +1 more source

Using Pattern Languages in Participatory Design [PDF]

In this paper, we examine the contribution that pattern languages could make to user participation in the design of interactive systems, and we report on our experiences of using pattern languages in this way. In recent years, there has been a growing
Allgar, E, Dearden, A, Finlay, J, McManus, B   +3 more
core  

A New Consumerism: The influence of social technologies on product design [PDF]

, 2014
Social media has enabled a new style of consumerism. Consumers are no longer passive recipients; instead they are assuming active and participatory roles in product design and production, facilitated by interaction and collaboration in virtual ...
de Vere, I
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

When we talk about time, we mean many different things: employing visual mapping to think through more-than-human temporalities in participatory design

Frontiers in Communication
In recent years, the scope of participatory design has broadened to encompass perspectives and approaches beyond the human realm. This expansion requires considering multiple aspects to fully capture ‘more-than-humans’ diversity and concerns.
Hadas Zohar, Luca Simeone, Amalia de Götzen, Nicola Morelli   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Participatory policy evaluation as an innovative method to improve processes of sustainable rural development [PDF]

This paper presents an innovative process-orientated self-evaluation method regarding sustainable rural development processes, developed by the University of Göttingen in cooperation with rural actors and a consultant.
Bocher, Michael
core   +1 more source