Results 161 to 170 of about 10,003,240 (243)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Developing a Customizable Texting Intervention for Diabetes Self-Management: Participatory Design Approach. [PDF]

JMIR Form Res
Robinson SA, Shell P, Am L, Bilodeau CL, Gordon HS, Uphold CR, Vimalananda VG, Cutrona SL, Hogan TP, Smith B, Shimada SL.   +10 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Correction: Community-based participatory design of a decade: the FAITH! Cardiovascular Health and Wellness Program. [PDF]

Front Public Health
Brewer LC, Lalika M, Kyalwazi AN, Albertie M, Bowie J, Burgess A, Burke LE, Buta B, Cooper LA, Crews DC, Doubeni CA, Elegbede W, Erickson J, Jenkins S, Johnson J, Jones C, Krogman A, Moen L, Palmer M, Patten CA, Penheiter S, Richard MW, Titus P, Schardin S, Shanedling S, Van't Hof JR, Warner D, Weis J, Hayes SN.   +28 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Co-Designing a Text Messaging Intervention for Youth Transitioning From Child to Adult Mental Health Services: Participatory Design Jam Study. [PDF]

JMIR Form Res
Vakili N, Cassidy C, Chawla S, Curran JA, Munro S, Phillips D, Pho NSH, Walls R, Wood A, Wozney L.   +9 more
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Redesign of Bedside Supply Carts to Improve Emergency Department Workflows: Mixed Methods Participatory Design. [PDF]

JMIR Hum Factors
Hefter K, Dreibelbis S, Haupt T, McIver A, Wang A, Dwight J, Nwodim O, Ray N.   +7 more
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Strategies to Address Colorectal Cancer Screening Disparities Developed Through Community Based Participatory Design: A Mixed Methods Study. [PDF]

Cancer Med
Wendt SJ, Roybal KL, Haggerty J, Millen JC, Leslie A, Rountree JA, Weiss J, Gupta H, Bilchik A.   +8 more
europepmc   +1 more source