Results 101 to 110 of about 9,595,710 (283)

Exploring Spatial Expectations in a Natural Playground Designed by Children for Kindergartens

Buildings
Natural playgrounds in early childhood education support children’s development and environmental awareness by offering various experiences. However, in many kindergartens, natural playgrounds are insufficient, and it is emphasized that playgrounds ...
B. Ece Şahin, Sibel Polat, A. Burcu Zülfikar, Hande Akar   +3 more
doaj   +1 more source

Living Labs for Open-Ended Participatory Design

Malmö Living Labs (2007–2017) built on a Scandinavian Participatory Design approach and aimed to explore how processes of change in the City of Malmö could be further democratised.
Linde, Per,, Hillgren, Per-Anders,, Nilsson, Elisabet M.,, Ehn, Pelle,, Smedberg, Alicia,, Eriksen, Mette A.,   +5 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Getting Closer, Empathising and Understanding: Setting the Stage for a Co-design Project with People with Dementia [PDF]

Interaction Design and Architecture(s), 2015
This paper discusses the initial work of a doctoral research project that explores how communication design can enable people with dementia and their social circle to codesign strategies to communicate.
Rita Maldonado Branco, Joana Quental, Óscar Ribeiro   +2 more
doaj  

Participatory Design: an introduction

, 2012
The aim of this book is to provide a current account of the commitments and contributions of research and practice in the Participatory Design of information technologies.
Robertson, TJ, Simonsen, J, Robertson, Toni, Simonsen, Jesper   +3 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Participatory design and participatory development: a comparative review [PDF]

, 2008
This paper examines literature in the twin domains of participatory interactive systems design and participatory approaches to international development. As interactive systems are increasingly promoted as a possible means of achieving international development goals, designers generally agree that participatory design approaches should be applied ...
Dearden, Andy, Rizvi, H.
openaire   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Revisiting the origins of participatory design. A review from the south

ARQUISUR Revista
Participatory design addresses the project activity from a multiactoral and inclusive approach. Focusing on design, this article specifically reconstructs the history of a participatory approach to architectural design.
Juan Santiago Palero
doaj   +1 more source