Results 91 to 100 of about 9,595,710 (283)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Use of an interdisciplinary, participatory design approach to develop a usable patient self-assessment tool in atrial fibrillation

Patient Preference and Adherence, 2013
Lori MacCallum,1,2 Heather McGaw,1 Nazanin Meshkat,3 Alissia Valentinis,4 Leslie Beard Ashley,5 Rajan Sacha Bhatia,3,6,7 Kaye Benson,7 Noah Ivers,6,8 Kori Leblanc,2,7 Dante Morra3,5,7 1Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto ...
MacCallum L, McGaw H, Meshkat N, Valentinis A, Beard Ashley L, Bhatia RS, Benson K, Ivers N, Leblanc K, Morra D   +9 more
doaj  

The barriers of participatory landscape design approaches based on experts’ opinions [PDF]

علوم محیطی, 2017
Introduction: Nowadays, it is not acceptable to design an unchangeable plan, especially in landscape architecture where end-users should be at the center of any design.
Mahda Foroughi, Saeid Norouzian-Maleki, Moeen Hajimaghsoudi   +2 more
doaj  

DESIGN-BASED APPROACHES TO ENGAGE YOUTH IN THE TRANSITION TO SUSTAINABILITY

Abordagens de Design para Engajar os Jovens na Transição para a Sustentabilidade

Mix Sustentável, 2017
This research aims to study how the integration of design thinking and participatory design applied to education experiences can promote engagement in sustainability and pro-environmental behavior among young students.
Najla Mouchrek
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

From Practice to Policy: Reflections from the Participatory Process to Design a Development Education Strategy in Valencia (Spain)

Policy and Practice: A Development Education Review, 2017
This article will reflect on the participatory process and content of the Education for Development Strategy (for the formal education sector) of the Autonomous Community of Valencia.
Alejandra Boni
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Toward a Participatory Design Approach to Service Design

, 2004
This paper introduces service design as a potential Participatory Design (PD) theme. It proposes that the success of designing good services can be increased by including the perspectives and practices of the future service participants into the design ...
Sangiorgi, Daniela, Clark, Brendon
core   +1 more source

A new approach to improve outpatient departments to mitigate respiratory infectious diseases

Journal of Asian Architecture and Building Engineering
Spatial design and management in many hospitals across Asia continue to face challenges in meeting infection control requirements in outpatient departments (OPDs), along with limited user participation in design processes.
Jutamat Chotirat, Kantaphong Srimuang, Reyes Garcia, Supuck Prugsiganont van der Hoeven   +3 more
doaj   +1 more source