Results 91 to 100 of about 10,003,240 (243)

A new approach to improve outpatient departments to mitigate respiratory infectious diseases

Journal of Asian Architecture and Building Engineering
Spatial design and management in many hospitals across Asia continue to face challenges in meeting infection control requirements in outpatient departments (OPDs), along with limited user participation in design processes.
Jutamat Chotirat, Kantaphong Srimuang, Reyes Garcia, Supuck Prugsiganont van der Hoeven   +3 more
doaj   +1 more source

Exploring Spatial Expectations in a Natural Playground Designed by Children for Kindergartens

Buildings
Natural playgrounds in early childhood education support children’s development and environmental awareness by offering various experiences. However, in many kindergartens, natural playgrounds are insufficient, and it is emphasized that playgrounds ...
B. Ece Şahin, Sibel Polat, A. Burcu Zülfikar, Hande Akar   +3 more
doaj   +1 more source

Getting Closer, Empathising and Understanding: Setting the Stage for a Co-design Project with People with Dementia [PDF]

Interaction Design and Architecture(s), 2015
This paper discusses the initial work of a doctoral research project that explores how communication design can enable people with dementia and their social circle to codesign strategies to communicate.
Rita Maldonado Branco, Joana Quental, Óscar Ribeiro   +2 more
doaj  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Subversive participatory design

, 2016
This paper grounds in a research experience for engaging older people as co-designers of several wearable and in-house technologies. We start by describing a case study that is a pre-commercial procurement aimed at developing innovative services for the ...
Vincenzo D'Andrea, D'Andrea, Vincenzo,, Tonolli, Linda,, Michela Cozza, Linda Tonolli, Cozza, Michela,   +5 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Toward a Participatory Design Approach to Service Design [Elektronisk resurs]

, 2004
This paper introduces service design as a potential Participatory Design (PD) theme. It proposes that the success of designing good services can be increased by including the perspectives and practices of the future service participants into the design ...
Clark, Brendon,, Sangiorgi, Daniela
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source