Results 81 to 90 of about 71,336 (260)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

From Practice to Policy: Reflections from the Participatory Process to Design a Development Education Strategy in Valencia (Spain)

Policy and Practice: A Development Education Review, 2017
This article will reflect on the participatory process and content of the Education for Development Strategy (for the formal education sector) of the Autonomous Community of Valencia.
Alejandra Boni
doaj  

Digitising the Physical: The Evolving Role of Collaboration Tools in Citizen Participatory Design Amidst the COVID-19 Pandemic in Seoul

Temes de Disseny
This case study investigates how the digital transformation of urban design governance following the COVID-19 outbreak has led to changes in approaches to citizen participatory design in Seoul, South Korea.
Oxana Jeoung-Rakova
doaj   +1 more source

Involving Older People in Participatory Action Research: An Example of Participatory Action Design

Romanian Journal of Communications and Public Relations, 2018
Participatory Action Research (PAR) has as a main goal the collaborative construction and production of meanings between the researchers and the participants.
Ioana Schiau, Loredana Ivan, Monica Bîră   +2 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The barriers of participatory landscape design approaches based on experts’ opinions [PDF]

علوم محیطی, 2017
Introduction: Nowadays, it is not acceptable to design an unchangeable plan, especially in landscape architecture where end-users should be at the center of any design.
Mahda Foroughi, Saeid Norouzian-Maleki, Moeen Hajimaghsoudi   +2 more
doaj  

DESIGN-BASED APPROACHES TO ENGAGE YOUTH IN THE TRANSITION TO SUSTAINABILITY

Abordagens de Design para Engajar os Jovens na Transição para a Sustentabilidade

Mix Sustentável, 2017
This research aims to study how the integration of design thinking and participatory design applied to education experiences can promote engagement in sustainability and pro-environmental behavior among young students.
Najla Mouchrek
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Exploring Spatial Expectations in a Natural Playground Designed by Children for Kindergartens

Buildings
Natural playgrounds in early childhood education support children’s development and environmental awareness by offering various experiences. However, in many kindergartens, natural playgrounds are insufficient, and it is emphasized that playgrounds ...
B. Ece Şahin, Sibel Polat, A. Burcu Zülfikar, Hande Akar   +3 more
doaj   +1 more source