Results 91 to 100 of about 1,348,580 (296)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Participatory Transnational Governance [PDF]

, 2006
In textbooks and in theory, law is a product of democratic procedures. In reality, however, the place of law production has moved to a significant degree from the domestic sphere into an emerging domain of supranational and international institutions, bodies, and organizations, public or private, which constitute and enforce "global law without a state"
openaire   +2 more sources

Tabling sustainable commodities through private governance [PDF]

, 2013
Over the past few decades, new types of private governance arrangements arose which increasingly shape outcomes in global governance. The object of this dissertation is a specific form of private governance arrangement which emerged in the early 2000s in
Environmental Governance, Schouten, A.M., Section Environmental Governance   +2 more
core  

Assessing the interactions of people and policy-makers in social participation for health: an inventory of participatory governance measures from a rapid systematic literature review. [PDF]

Int J Equity Health, 2023
Gupta P, Rouffy-Ly B, Rohrer-Herold K, Koch K, Rao N, Poulussen C, Brearley L, Abou-Taleb H, Rajan D.   +8 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

What can data trusts for health research learn from participatory governance in biobanks? [PDF]

J Med Ethics, 2022
Milne R, Sorbie A, Dixon-Woods M.
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The ESG–Democracy Interface

Campos Neutrais
This paper examines the relationship between democratic quality and Environmental, Social, and Governance (ESG)-related governance through a comparative legal-institutional approach.
Gabriel Vieira Terenzi, Fernando Alves
doaj   +3 more sources

DAMPAK PENERAPAN GOOD UNIVERSITY GOVERNANCE TERHADAP KINERJA MANAJERIAL MELALUI IMPLEMENTASI ANGGARAN BERBASIS PARTISIPATIF

Jurnal Akuntansi, 2017
The purpose of this study to examine the impact of the implementation of Good University Governance Principles on managerial performance in the practice of participatory-based budget management.
Amilin Amilin
doaj   +1 more source