Results 141 to 150 of about 561,914 (308)

Culturally responsive approaches to cultivate care and innovation among emerging public health leaders for ethical community engagement: perspectives informed through lived experience

Frontiers in Public Health
Traditional methods of public health research, practice, and education continue to overlook the value of multidisciplinary approaches to research, practice, and training in addressing health problems.
Marina Suzanne Hernandez, Ruth Murcia
doaj   +1 more source

Community-Engaged Participatory Methods to Address Lesbian, Gay, Bisexual, Transgender, Queer, and Questioning Young People's Health Information Needs With a Resource Website: Participatory Design and Development Study. [PDF]

JMIR Form Res, 2023
Delmonaco D, Li S, Paneda C, Popoff E, Hughson L, Jadwin-Cakmak L, Alferio J, Stephenson C, Henry A, Powdhar K, Gierlinger I, Harper GW, Haimson OL.   +12 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

When digital technologies stumble: Exnovating for conservation science and practice

Conservation Science and Practice
Digital technologies are rapidly transforming conservation efforts in response to pressing planetary environmental challenges. However, these expanding innovations also introduce significant risks and failures that can deepen existing injustices ...
Danilo Urzedo, Sabrina Chakori
doaj   +1 more source

Participatory Methods for Systems Modeling of Youth Mental Health: Implementation Protocol. [PDF]

JMIR Res Protoc, 2022
Freebairn L, Occhipinti JA, Song YJC, Skinner A, Lawson K, Lee GY, Hockey SJ, Huntley S, Hickie IB.   +8 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Investigating a psychological model of mental conditions and coping during the COVID-19 pandemic driven by participatory methods. [PDF]

Soc Psychiatry Psychiatr Epidemiol, 2022
Simblett SK, Jilka S, Vitoratou S, Hayes C, Morris D, Wilson E, Odoi C, Mutepua M, Evans J, Negbenose E, Jansli SM, Hudson G, Adanijo A, Dawe-Lane E, Pinfold V, Wykes T.   +15 more
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Crafting During Coronavirus: participatory methods with older adults during COVID-19. [PDF]

Z Gerontol Geriatr, 2023
Clarke N.
europepmc   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source