Results 91 to 100 of about 765,758 (302)

Pediatric oncology healthcare professionals’ attitudes to and awareness of regulations for minors’ and guardians’ online record access: a mixed-methods study in Sweden

BMC Health Services Research
Background Healthcare providers and policymakers worldwide differ in their provision of access to adolescent patients’ electronic health records (EHR). The regulatory framework in Sweden restricting both guardians’ and adolescents’ online record access ...
Josefin Hagström, Charlotte Blease, Arja Harila, Isabella Scandurra, Päivi Lähteenmäki, Maria Hägglund   +5 more
doaj   +1 more source

Participatory epidemiology: the contribution of participatory research to epidemiology

Emerging Themes in Epidemiology, 2017
Background Epidemiology has contributed in many ways to identifying various risk factors for disease and to promoting population health. However, there is a continuing debate about the ability of epidemiology not only to describe, but also to provide ...
Mario Bach, Susanne Jordan, Susanne Hartung, Claudia Santos-Hövener, Michael T. Wright   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A culturally-focused life cycle sustainability assessment: Analysis of forestry value chain options with Māori land owners : A thesis presented in partial fulfilment of the requirements of Doctor of Philosophy in Life Cycle Management At Massey University, Palmerston North, New Zealand [PDF]

, 2016
The purpose of this research was to 1) explore the potential for the more distinctive representation of Māori culture in Life Cycle Sustainability Assessment (LCSA), and 2) understand the relationship between culturally-focused LCSA and the Māori ...
Pizzirani, Stefania Maria
core  

Participatory mass observation and citizen science. [PDF]

, 2011
The authors outline and reflect upon a new research agenda on participatory mass observation and citizen science as an introduction to the 3 project outlines in this special section of ...
Ellis, Rebecca, Hemment, Drew, Wynne, Brian   +2 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Sustainable political commitment is necessary for institutionalizing community participation in health policy-making: Insights from Iran

Health Research Policy and Systems
Background Community participation is currently utilized as a national strategy to promote public health and mitigate health inequalities across the world.
Maryam Rahbari Bonab, Fatemh Rajabi, Abouali Vedadhir, Reza Majdzadeh   +3 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source