Results 91 to 100 of about 103,804 (258)
Digital HealthBackground Following the launch of ChatGPT in November 2022, interest in large language model-powered chatbots has soared with increasing focus on the clinical potential of these tools.
Charlotte Blease +10 more
doaj +1 more source
From urban crime areas to urban resilience: lessons learned from Bandung City, Indonesia
Cogent Social SciencesThe aim of this study was to determine the factors of urban crime and their impact on realizing urban resilience in Bandung City, Indonesia, and at the same time explore urban governance and policies in dealing with these problems.
Abdillah +3 more
doaj +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Inclusion of Community-Based Participatory Research in High-Impact Medical Journals
Health EquityCommunity-based participatory research (CBPR) is essential for addressing health care inequities; however, it is unclear to what extent articles published in high-impact medical journals use CPBR.
Michelle Doughtery +9 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Participatory Evaluation of Participatory Research
Participatory Evaluation of Participatory Researchこの講演では、1)研究・開発事業における評価という役割の変化、2)事業評価における参加型アプローチという新しい手法の誕生と3)参加型研究の評価という新たな分野への朝鮮とその課題について述べる。キーとなる重要な概念と実践方法を理解していただくために、アジアで実際に行われた農業研究と開発関連の実例を使いながら話をすすめていきたい。研究・開発事業では、評価は、説明責任と透明さを確実なものとするためのただ単なる手段として今までみなされていた。評価は事業がその目的を達成したか、資源を有効に使うことができたかどうかを図るためによく使われるが、これは公の場において公正さの審査を受けるためである。ほとんどの評価事業はプロジェクトの提案者、実施者とドナーのニーズにこたえるように組み立てられている。評価は、私意のない ...
openaire +1 more source
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source