Results 111 to 120 of about 765,758 (302)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Learning in context – improved nutrient management in arable cropping systems through participatory research [PDF]

, 2008
Participatory research (PR) provides opportunities to build knowledge relevant to site-specific farms conditions. This study used a PR approach to develop nutrient management strategies in stockless organic farming.
Naetterlund, Henrik, Wivstad, Maria
core  

Participatory democracy and participatory research

European Political Science Review
AbstractWhile normative theories of participatory democracy and practical experiences of participatory research share a common democratic commitment, the two fields have emerged and to date exist in isolation from each other. This article bridges this divide and asks what participatory democracy and participatory research can learn from one another. It
Hans Asenbaum, Sonia Bussu, Oliver Escobar, Clodagh Harris   +3 more
openaire   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Organization ecosystem for inclusive development in Indonesia: a bibliometric analysis and literature review

Cogent Social Sciences
This study aims to identify, review, and study trends in scientific publications on organizational ecosystems for inclusive development in Indonesia. This study examines how organizations can address issues of diversity, equity, and inclusion (DEI), in ...
Heru Nurasa, Abdillah Abdillah, Qinthara Mubarak Adikancana, Ida Widianingsih   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Youth Reproductive Health in Nepal: Is Participation the Answer? [PDF]

, 2004
Discusses the processes and results of a multi-year research study by ICRW, EngenderHealth, and Nepali partners, which tested the effectiveness of the participatory approach in defining and addressing the reproductive health concerns of ...
Anju Malhotra, Manisha Mehta, Sanyukta Mathur   +2 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

UTILITATEA ŞI RELEVANŢA CERCETĂRII PARTICIPATIVE ÎN INVESTIGAREA FENOMENELOR SOCIALE

Studia Universitatis Moldaviae: Stiinte Sociale, 2017
În acest articol este luată în vizor o nouă paradigmă de cercetare a fenomenelor sociale, care pune accentul pe abor­darea participativă: actorii sociali studiaţi devin membri ai echipelor de cercetare, favorizând cunoaşterea din interior şi aprofundată ...
Anastasia OCERETNÎI
doaj  

Organizing Facilitated Poster Discussion Sessions: Their Inspiration, Planning, and Implementation at the C*Sci2023 Conference

Citizen Science: Theory and Practice
The C*Sci 2023 conference, held by the Association for the Advancement of Participatory Sciences (AAPS; until 2024 known as the Citizen Science Association) in Tempe, Arizona in May 2023, aimed to bring those involved in participatory science together in
Sara Duncan, Alison Cawood, Julie Tuttle, Reanna Putnam   +3 more
doaj   +1 more source