Results 141 to 150 of about 512,213 (312)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Discover Applied SciencesClimate change has contributed to an increase in natural catastrophes over the past five years in Indonesia, causing various forms of damage in urban areas and posing a severe danger to multi-risk governance for municipal governments in Indonesia.
Abdillah Abdillah +3 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
DIY networking as a facilitator for interdisciplinary research on the hybrid city [PDF]
, 2015 DIY networking is a technology with special characteristics compared to the public Internet, which holds a unique potential for empowering citizens to shape their hybrid urban space toward conviviality and collective awareness.
Antoniadis, Panayotis +4 more
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Does Empirical Embeddedness Matter? Methodological Issues on Agent-Based Models for Analytical Social Science [PDF]
The paper deals with the use of empirical data in social science agent-based models. Agent-based models are too often viewed just as highly abstract thought experiments conducted in artificial worlds, in which the purpose is to generate and not to test ...
Flaminio Squazzoni, Riccardo Boero
core
Requirements for Participatory Framework on Governmental Policy Level [PDF]
, 2012 The article seeks to specify the requirements of the framework for public participation in policy making on the governmental level aiming to elaborate a substantial content of the participatory policy.
Birutė MIKULSKIENĖ +1 more
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Frontiers in Marine ScienceCollaborative fisheries research programs engage stakeholders in data collection efforts, often with the benefit of increasing transparency about the status and management of natural resources. These programs are particularly important in marine systems,
Erin M. Johnston +28 more
doaj +1 more source