Results 91 to 100 of about 512,842 (292)
, 2007 Two cases of weakly and strongly stressed X-point collapse were considered. Here descriptors weakly and strongly refer to 20 % and 124 % unidirectional spatial compression of the X-point, respectively.
Biskamp D. +6 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
, 2014 We perform first-principles relativistic particle-in-cell simulations of aligned pulsar magnetosphere. We allow free escape of particles from the surface of a neutron star and continuously populate the magnetosphere with neutral pair plasma to imitate ...
Philippov, Alexander +1 more
core +1 more source
Simulations of a kinetic plasma instability in streamers of transient luminous events
Archives of MechanicsWe have supplemented the Particle-In-Cell code SMILEI with the module for collisions between charged and neutral particles. The code has been evaluated and used for the examination of the nonlinear stability and dynamics of plasma in conditions of ...
P. Jujeczko, J. Błęcki, K.A. Mizerski
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Load management strategy for Particle-In-Cell simulations in high energy particle acceleration
, 2016 In the wake of the intense effort made for the experimental CILEX project, numerical simulation cam- paigns have been carried out in order to finalize the design of the facility and to identify optimal laser and plasma parameters. These simulations bring,
Beck, Arnaud +2 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Relativistic Particle-In-Cell Simulation Studies of Prompt and Early Afterglows from GRBs
, 2008 Nonthermal radiation observed from astrophysical systems containing relativistic jets and shocks e.g. gamma-ray bursts (GRBs) active galactic nuclei (AGNs) and microquasars commonly exhibit power-law emission spectra.
David Palmer +7 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source