Results 61 to 70 of about 67,146 (302)

Solar Particle Acceleration

Astronomy
High-energy particles may be accelerated widely in stellar coronae; probably by the same processes we find in the Sun. Here, we have learned of two physical mechanisms that dominate the acceleration of solar energetic particles (SEPs).
Donald V. Reames
doaj   +1 more source

A Model for Nonthermal Particle Acceleration in Relativistic Magnetic Reconnection

The Astrophysical Journal Letters, 2023
The past decade has seen an outstanding development of nonthermal particle acceleration in magnetic reconnection in magnetically dominated systems, with clear signatures of power-law energy distributions as a common outcome of first-principles kinetic ...
Xiaocan Li, Fan Guo, Yi-Hsin Liu, Hui Li
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Particle acceleration in subcycle optical cells

Physical Review Special Topics. Accelerators and Beams, 2014
A single laser pulse with spot size smaller than half its wavelength (w_{0}
F. Terranova
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Characterizing Particle-Scale Acceleration of Mud-Pumping Ballast Bed of Heavy-Haul Railway Subjected to Maintenance Operations

Sensors, 2022
Fouling and mud-pumping problems in ballasted track significantly degrade serviceability and jeopardize train operational safety. The phenomenological approaches for post hoc forensic investigation and remedies of mud pumps have relatively been well ...
Meng Wang, Yuanjie Xiao, Wenqi Li, Hongjun Zhao, Wenjun Hua, Yu Jiang   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Particles in Relativistic MHD Jets. I. Role of Jet Dynamics in Particle Acceleration

The Astrophysical Journal, 2023
Relativistic jets from (supermassive) black holes are typically observed in nonthermal emission, caused by highly relativistic electrons. Here, we study the interrelation between three-dimensional (special) relativistic magnetohydrodynamics, and particle
Ravi Pratap Dubey, Christian Fendt, Bhargav Vaidya   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Nonlinear interaction of charged particles with strong laser pulses in a magnetic undulator

Physical Review Special Topics. Accelerators and Beams, 2010
Laser acceleration due to the nonlinear-threshold phenomena of charged particle “reflection” and capture by slowed wave in a magnetic undulator is considered. The obtained numerical results prove the particle reflection and capture phenomena in the field
H. K. Avetissian, Kh. V. Sedrakian
doaj   +1 more source