Results 51 to 60 of about 170,044 (337)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Implementing NLO DGLAP evolution in parton showers

Journal of High Energy Physics, 2017
We present a parton shower which implements the DGLAP evolution of parton densities and fragmentation functions at next-to-leading order precision up to effects stemming from local four-momentum conservation.
Stefan Höche, Frank Krauss, Stefan Prestel   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Preconditioned flow as a solution to the hierarchical growth problem in the generalized Lefschetz thimble method

Journal of High Energy Physics
The generalized Lefschetz thimble method is a promising approach that attempts to solve the sign problem in Monte Carlo methods by deforming the integration contour using the flow equation.
Jun Nishimura, Katsuta Sakai, Atis Yosprakob   +2 more
doaj   +1 more source

LHC signals of triplet scalars as dark matter portal: cut-based approach and improvement with gradient boosting and neural networks

Journal of High Energy Physics, 2020
We consider a scenario where an SU(2) triplet scalar acts as the portal for a scalar dark matter particle. We identify regions of the parameter space, where such a triplet coexists with the usual Higgs doublet consistently with all theoretical as well as
Atri Dey, Jayita Lahiri, Biswarup Mukhopadhyaya   +2 more
doaj   +1 more source

Transverse Beam Profiles

, 2020
The performance and safe operation of a particle accelerator is closely connected to the transverse emittance of the beams it produces. For this reason many techniques have been developed over the years for monitoring the transverse distribution of ...
Bravin, Enrico
core  

Particle collisions near a three-dimensional warped AdS black hole

, 2017
In this paper we consider the warped AdS$_{3}$ black hole solution of topologically massive gravity with a negative cosmological constant, and we investigate the possibility that it acts as a particle accelerator by analyzing the energy in the center of ...
Bécar, Ramón, González, P. A., Vásquez, Yerko   +2 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Synthesis mechanism from graphene quantum dots to carbon nanotubes by ion-sputtering assisted chemical vapor deposition

Discover Nano
We present the first work of the synthesis mechanism from graphene quantum dots (GQDs) to carbon nanotubes (CNTs) by an ion-sputtering assisted chemical vapor deposition.
Jun Mok Ha, Seoung Ho Lee, Daehyeon Park, Young Jun Yoon, In Mok Yang, Junhyeok Seo, Yong Seok Hwang, Chan Young Lee, Jae Kwon Suk, Jun Kue Park, Sunmog Yeo   +10 more
doaj   +1 more source