Results 51 to 60 of about 3,052,189 (295)

An investigation into the fraction of particle accelerators among colliding-wind binaries - Towards an extension of the catalogue [PDF]

open access: yes, 2017
Particle-accelerating colliding-wind binaries (PACWBs) are multiple systems made of early-type stars able to accelerate particles up to relativistic velocities.
M. Becker   +6 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Particle Accelerators [PDF]

open access: yes, 1955
In the most general sense, an accelerator is any device designed to give kinetic energy to ions or electrons. According to this definition the earliest cathode ray and canal ray tubes, made before the turn of the century were accelerators, the same principle is used in the x-ray tube, the cathode ray oscilloscope, the mass spectrograph, the electron ...
openaire   +4 more sources

Emittance preservation in a plasma-wakefield accelerator

open access: yesNature Communications
Radio-frequency particle accelerators are engines of discovery, powering high-energy physics and photon science, but are also large and expensive due to their limited accelerating fields.
C. A. Lindstrøm   +17 more
doaj   +1 more source

Uncertainty quantification for deep learning in particle accelerator applications

open access: yesPhysical Review Accelerators and Beams, 2021
With the advent of increased computational resources and improved algorithms, machine learning-based models are being increasingly applied to complex problems in particle accelerators.
Aashwin Ananda Mishra   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Design and first operation of a supersonic gas jet based beam profile monitor

open access: yesPhysical Review Accelerators and Beams, 2017
Noninterceptive beam profile monitors are of great importance for many particle accelerators worldwide. Extra challenges are posed by high energy, high intensity machines and low energy low intensity accelerators.
Vasilis Tzoganis   +3 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Operational and design aspects of accelerators for medical applications

open access: yesPhysical Review Special Topics. Accelerators and Beams, 2015
Originally, the typical particle accelerators as well as their associated beam transport equipment were designed for particle and nuclear physics research and applications in isotope production.
Jacobus Maarten Schippers, Mike Seidel
doaj   +1 more source

On the compatibility of porous surfaces with cryogenic vacuum in future high-energy particle accelerators

open access: yesApplied Physics Letters, 2019
Recently, pulsed laser processing of Cu samples has been demonstrated to produce rough surfaces whose structuring at the nanoscale ensures an impressive reduction of the secondary electron yield.
L. Spallino   +3 more
semanticscholar   +1 more source

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