Results 41 to 50 of about 3,447 (214)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The X-ray properties and structure of A3571 up to R500

open access: yesAstronomy & Astrophysics
Abell 3571 is a nearby, X-ray-bright galaxy cluster located in the Shapley Supercluster. Although it appears morphologically relaxed in X-ray images, multiwavelength observations reveal subtle indications of residual dynamical activity likely associated ...
Zheng X.   +24 more
doaj   +1 more source

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Amplitude analysis and branching fraction measurement of the decay D s + $$ {D}_s^{+} $$ → K + π + π −

open access: yesJournal of High Energy Physics, 2022
Using 6.32 fb −1 of e + e − collision data collected at the center-of-mass energies between 4.178 and 4.226 GeV with the BESIII detector, we perform an amplitude analysis of the decay D s + $$ {D}_s^{+} $$ → K + π + π − and determine the amplitudes of ...
The BESIII collaboration   +558 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Amplitude analysis and branching-fraction measurement of D s + $$ {\mathrm{D}}_{\mathrm{s}}^{+} $$ → π + π 0 η′

open access: yesJournal of High Energy Physics, 2022
Using data collected with the BESIII detector in e + e − collisions at center-of-mass energies between 4.178 and 4.226 GeV and corresponding to 6.32 fb −1 of integrated luminosity, we report the amplitude analysis and branching-fraction measurement of ...
The BESIII collaboration   +518 more
doaj   +1 more source

Nontrivial Isometric Embeddings for Flat Spaces

open access: yesUniverse, 2021
Nontrivial isometric embeddings for flat metrics (i.e., those which are not just planes in the ambient space) can serve as useful tools in the description of gravity in the embedding gravity approach.
Sergey Paston, Taisiia Zaitseva
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Observation of the doubly Cabibbo-suppressed decays D + → K + π 0 π 0 and D + → K + π 0 η

open access: yesJournal of High Energy Physics, 2022
By analyzing e + e − annihilation data corresponding to an integrated luminosity of 2.93 fb −1 collected at the center-of-mass energy of 3.773 GeV with the BESIII detector, we report the first observations of the doubly Cabibbo-suppressed decays D + → K +
The BESIII collaboration   +503 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

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