Results 71 to 80 of about 6,416,888 (307)

Variable smoothing lengths and energy conservation in smoothed particle hydrodynamics [PDF]

Monthly Notices of the Royal Astronomical Society, 1994
We present a new formulation of the equations of motion used in smoothed particle hydrodynamics (SPH). The spatial resolution in SPH is determined by the smoothing length, $h$, and it has become common practice for each particle to be given its own adaptive smoothing length, $h_i$.
Nelson, Richard P., Papaloizou, John C. B.   +1 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Anisotropic Diffusion of Elongated Particles in Active Coherent Flows

Micromachines
The study of particle diffusion, a classical conundrum in scientific inquiry, holds manifold implications for various real-world applications. Particularly within the domain of active flows, where the motion of self-propelled particles instigates fluid ...
Dongdong Li, Yanan Liu, Hao Luo, Guangyin Jing   +3 more
doaj   +1 more source

Two-particle correlation length in fireball models

Physics Letters B, 1973
Abstract It is pointed out that all models in which particle production occurs via an intermediate step of isotropically decaying fireballs, predict the existence of the positive short-range component in two-particle inclusive correlations. The correlation lenght is predicted to be about one, in agreement with existing data.
A. Białas, K. Fiałkowski, K. Zalewski
openaire   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

An Adaptive SPH Method (ADP‐SPH) for Simulating Solute Transport in Heterogeneous Aquifers

Water Resources Research
Smoothed Particle Hydrodynamics (SPH) is a meshfree, Lagrangian‐based approach used to solve the advection‐dispersion equation (ADE) of groundwater solute transport.
Tian Jiao, Ming Ye, Jinxi Song, Jing Yang, Maosheng Yin   +4 more
doaj   +1 more source

Influence of fibrolytic enzymes on ruminal disappearance and fermentation in steers fed diets with short and long particle length of forage

Italian Journal of Animal Science, 2010
The effects of an exogenous fibrolytic enzyme mixture on in sacco ruminal disappearance and fermentation of growing (380 kg body weight) and finishing (440 kg body weight) steers fed with diets to short (10 mm) and long (50 mm) particle length (PL) were ...
Germán Mendoza, Sergio Segundo González, Ricardo Bárcena, Juan Manuel Pinos- Rodríguez, Lorenzo Carreón   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source