Results 91 to 100 of about 1,114,868 (291)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Influence of Particle Elongation and Aspect Ratio on the Discharge Behavior of a Flat-Bottom Silo

KONA Powder and Particle Journal
Silos are widely used structures designed with hoppers or as flat bottoms to store different types of particulate materials (pellets, grains, powders, etc.). Although they have been used in industry for a long time, further research is needed.
Yani Alhaddad, Álvaro Ramírez-Gómez
doaj   +1 more source

Dynamics of a trapped Brownian particle in shear flows

, 2010
The Brownian motion of a particle in a harmonic potential, which is simultaneously exposed either to a linear shear flow or to a plane Poiseuille flow is investigated.
G. G. Stokes, J. K. G. Dhont, Jochen Bammert, L. D. Landau, L. D. Landau, L. E. Reichl, Lukas Holzer, N. G. van Kampen, P. G. deGennes, Roland Rzehak, Walter Zimmermann   +10 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Influence of manufacturing process on fundamental properties of NiCoCrAlY powders

Fenmo yejin jishu
NiCoCrAlY powders was prepared by plasma rotating electrode process (PREP), vacuum gas atomization (VGA) and agglomeration-sintering method (ASM), respectively.
TIAN Jiale, WANG Chengxi, SONG Peng, HUANG Taihong, ZHANG Xiaowei   +4 more
doaj   +1 more source

Phase Separation and Self-Assembly in a Fluid of Mickey Mouse Particles

, 2015
Recent developments in the synthesis of colloidal particles allow for control over shape and inter-particle interaction. One example, among others, is the so-called "Mickey Mouse" (MM) particle for which the self-assembly properties have been previously ...
Avvisati, Guido, Dijkstra, Marjolein
core   +2 more sources

Effect of Particle Shape on the Flow of an Hourglass

Physical Review Letters
The flow rate of a granulate out of a cylindrical container is studied as a function of particle shape for flat and elongated ellipsoids experimentally and numerically. We find a nonmonotonic dependence of the flow rate on the grain aspect ratio a/b.
Bo Fan, Tivadar Pongó, Raúl Cruz Hidalgo, Tamás Börzsönyi   +3 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Experimental study on effect of particle shape on erosion intermittenting graded soils using transparent soil

Yantu gongcheng xuebao
Internal erosion is one of the main causes of seepage damage in natural sediments or geotechnical structures. In the seepage process, particle shape is an important factor affecting the development of erosion in soil.
ZHOU Hang 1, 2, WU Yuhan 1, 2, LIU Hanlong 1, 2, QI Geping 1, 2
doaj   +1 more source

Scattering by randomly oriented ellipsoids: Application to aerosol and cloud problems [PDF]

A program was developed for computing the scattering and absorption by arbitrarily oriented and randomly oriented prolate and oblate spheroids. This permits examination of the effect of particle shape for cases ranging from needles through spheres to ...
Asano, S., Hansen, J. E., Sato, M.
core   +1 more source