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Nuclear physics in particle therapy: a review [PDF]

Reports on Progress in Physics, 2016
Charged particle therapy has been largely driven and influenced by nuclear physics. The increase in energy deposition density along the ion path in the body allows reducing the dose to normal tissues during radiotherapy compared to photons. Clinical results of particle therapy support the physical rationale for this treatment, but the method remains ...
DURANTE, MARCO, Paganetti, Harald
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Charged particles and neutron trackers: Applications to particle therapy

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2020
Abstract The use of C, He and O as beam particles in Particle Therapy (PT) treatments is getting more and more widespread as a consequence of the enhanced relative biological effectiveness and oxygen enhancement ratio of such projectiles with respect to protons. The advantages in the tumor control probability, related to the improved efficacy of ions,
Mattei I., Battistoni G., De Simoni M., Dong Y., Embriaco A., Fischetti M., Gioscio E., Mancini-Terracciano C., Marafini M., Mirabelli R., Muraro S., Sarti A., Sciubba A., Solfaroli Camillocci E., Traini G., Valle S. M., Patera V.   +16 more
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The case for particle therapy

The British Journal of Radiology, 2006
Among the most important decisions facing the British Government regarding the treatment of cancer in the National Health Service (NHS) is the purchase of charged particle therapy (CPT) centres. CPT is different from conventional radiotherapy: the dose is deposited far more selectively in Bragg Peaks by either protons or "heavy" ions, such as carbon ...
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Particle radiation therapy

Cancer, 1985
Current interest in attempting to identify any therapeutic advantages of beams of heavy particles (heavier than electrons) over photons is based on differences in physical absorption and radiobiologic interactions. The article discusses: dose distributions in tissue, which are markedly different for particles than for high energy photons and so may be ...
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Motion management in particle therapy

Medical Physics, 2018
In this review article, we introduced the importance of “motion management” in advanced particle therapy. Several publications have reported that organ motion causes dose distribution disturbances due to interplay and blurring effects. Furthermore, motion can result in target dose miss and unwanted dose to healthy structures around the target. To avoid
Mori, Shinichiro, Knopf, Antje-Christin, Umegaki, Kikuo   +2 more
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Particle Beams for Cancer Therapy

Clinical Oncology, 2003
Particle beams from protons to carbon ions have a number of important advantages for radiation therapy. Besides the physical selectivity that makes ions especially efficient for deep-seated tumours and tumours close to critical organs, carbon ions with their enhanced relative biological effectiveness offer an additional biological advantage for slow ...
W K, Weyrather, J, Debus
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Radiation Therapy With Charged Particles

Seminars in Radiation Oncology, 2006
Charged particle beams can offer an improved dose conformation to the target volume as compared with photon radiotherapy, with better sparing of normal tissue structures close to the target. In addition, beams of ions heavier than (4)He exhibit a strong increase of the linear energy transfer in the Bragg peak as compared with the entrance region. These
Daniela, Schulz-Ertner, Oliver, Jäkel, Wolfgang, Schlegel   +2 more
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Particle-Mediated Gene Therapy of Wounds

Wound Repair and Regeneration, 2000
Gene therapy is becoming a reality, and it is a particularly attractive approach for wound healing, because the wound site is often exposed, the treatment and condition should be transient, and gene products such as growth factors and cytokines suffer from problems with bioavailability and stability.
J M, Davidson, T, Krieg, S A, Eming
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Nanoscale Particle Therapies for Wounds and Ulcers

Nanomedicine, 2010
'Small is beautiful' - this should be the slogan of nanoscientists. Indeed, working with particles less than 100 nm in size, nanotechnology is on the verge of providing a host of new materials and approaches, revolutionizing applied medicine. The obvious potential of nanotechnology has attracted considerable investment from governments and industry ...
Cortivo R, Vindigni V, Iacobellis L, Abatangelo G, PINTON, Paolo, Zavan B.   +5 more
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Alpha-particles for targeted therapy

Advanced Drug Delivery Reviews, 2008
Alpha-particles are helium nuclei that deposit DNA damaging energy along their track that is 100 to 1000 times greater than that of conventionally used beta-particle emitting radionuclides for targeted therapy; the damage caused by alpha-particles is predominately double-stranded DNA breaks severe enough so as to be almost completely irreparable.
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