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Motion management in particle therapy
Medical Physics, 2018In this review article, we introduced the importance of “motion management” in advanced particle therapy. Several publications have reported that organ motion causes dose distribution disturbances due to interplay and blurring effects. Furthermore, motion can result in target dose miss and unwanted dose to healthy structures around the target. To avoid
Mori, Shinichiro +2 more
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Charged particles and neutron trackers: Applications to particle therapy
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2020Abstract The use of C, He and O as beam particles in Particle Therapy (PT) treatments is getting more and more widespread as a consequence of the enhanced relative biological effectiveness and oxygen enhancement ratio of such projectiles with respect to protons. The advantages in the tumor control probability, related to the improved efficacy of ions,
Mattei I. +16 more
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Particle Beams for Cancer Therapy
Clinical Oncology, 2003Particle beams from protons to carbon ions have a number of important advantages for radiation therapy. Besides the physical selectivity that makes ions especially efficient for deep-seated tumours and tumours close to critical organs, carbon ions with their enhanced relative biological effectiveness offer an additional biological advantage for slow ...
W K, Weyrather, J, Debus
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Radiation Therapy With Charged Particles
Seminars in Radiation Oncology, 2006Charged particle beams can offer an improved dose conformation to the target volume as compared with photon radiotherapy, with better sparing of normal tissue structures close to the target. In addition, beams of ions heavier than (4)He exhibit a strong increase of the linear energy transfer in the Bragg peak as compared with the entrance region. These
Daniela, Schulz-Ertner +2 more
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Particle-Mediated Gene Therapy of Wounds
Wound Repair and Regeneration, 2000Gene therapy is becoming a reality, and it is a particularly attractive approach for wound healing, because the wound site is often exposed, the treatment and condition should be transient, and gene products such as growth factors and cytokines suffer from problems with bioavailability and stability.
J M, Davidson, T, Krieg, S A, Eming
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Antiviral therapy with small particle aerosols
European Journal of Clinical Microbiology & Infectious Diseases, 1988The generation and use of small particle aqueous aerosols (1.23 microns aerodynamic mass median diameter, GSD = 2.0 microns) containing ribavirin is described. Administered via aerosol, ribavirin will be deposited rather uniformly on the surface of the nasopharynx, the tracheobronchial tree and in the pulmonary area.
V, Knight, B, Gilbert
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Alpha-particles for targeted therapy
Advanced Drug Delivery Reviews, 2008Alpha-particles are helium nuclei that deposit DNA damaging energy along their track that is 100 to 1000 times greater than that of conventionally used beta-particle emitting radionuclides for targeted therapy; the damage caused by alpha-particles is predominately double-stranded DNA breaks severe enough so as to be almost completely irreparable.
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The British Journal of Radiology, 2006
Among the most important decisions facing the British Government regarding the treatment of cancer in the National Health Service (NHS) is the purchase of charged particle therapy (CPT) centres. CPT is different from conventional radiotherapy: the dose is deposited far more selectively in Bragg Peaks by either protons or "heavy" ions, such as carbon ...
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Among the most important decisions facing the British Government regarding the treatment of cancer in the National Health Service (NHS) is the purchase of charged particle therapy (CPT) centres. CPT is different from conventional radiotherapy: the dose is deposited far more selectively in Bragg Peaks by either protons or "heavy" ions, such as carbon ...
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American Journal of Clinical Oncology, 2008
With the arrival of 3-dimensional conformal radiation therapy and intensity modulated radiation therapy, radiation dose distributions in radiation oncology have improved dramatically over the past couple of decades. As part of a natural progression there recently has been a resurgence of interest in hadron therapy, specifically charged particle therapy,
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With the arrival of 3-dimensional conformal radiation therapy and intensity modulated radiation therapy, radiation dose distributions in radiation oncology have improved dramatically over the past couple of decades. As part of a natural progression there recently has been a resurgence of interest in hadron therapy, specifically charged particle therapy,
openaire +2 more sources
Percutaneous Transcatheter Particle Therapies
2019Given that only 20–30% of patients with hepatocellular carcinoma and colorectal liver metastases present with resectable disease, there has been an increasing role for the use of percutaneous transcatheter particle therapies in the management of unresectable hepatic malignancies.
Grace C. Lee +2 more
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