Results 91 to 100 of about 25,407 (286)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Hannah Arendt: Jew and Cosmopolitan
Socio, 2015 This paper deals with the difference between universalism and cosmo-politanism. If I understand correctly, what makes cosmopolitanism distinctive is that it is always rooted in a specific identity which realizes that it is specific, and always endeavours
Natan Sznaider
doaj +1 more source
Particularism in political decision-making: constructive or destructive [PDF]
, 2017 This paper is aimed at the impact of particularism in political decision-making. It is argued that political decisions are particularistic according to the goal and circumstances, in which they are made.
Vinnykova, N.
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Crítica, 2018 This article analyzes the thesis of ethical relativism, as defended by Alchourrón and Bulygin (1983). These authors offer, on the one hand, a suggestive conception according to which the question “what are our obligations?” is equivalent to thinking ...
J. J. Moreso
doaj +1 more source
Global game, local goals : football and the global-local nexus : a thesis in partial fulfilment of the degree of Master of Arts in Social Anthropology, Massey University, Albany [PDF]
, 2006 Association football is the most popular sport in the world with massive numbers of players and supporters, both male and female. The global spread of football coupled with its projection through mass media to global audiences suggests an analysis based ...
McAdam, Stuart Graeme
core