Results 71 to 80 of about 5,357 (285)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Tradition and Polyglossia

open access: yesSententiae
Oleksiy Panych put forward two theses: (1) irrelevance of the concept of national philosophical tradition in the analysis of modern philosophical processes; (2) impossibility of building such a tradition in contemporary Ukraine, since this tradition is ...
Oleg Khoma
doaj   +1 more source

Transient Particulars

open access: yesErgo an Open Access Journal of Philosophy
We spend much of our adult lives thinking and reminiscing about particular events of the past, which, by their very nature, can never be repeated. What is involved in a capacity to think thoughts of this kind? In this paper, I propose that such thoughts are essentially connected with a capacity to communicate about past events, and specifically in the ...
openaire   +3 more sources

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Moravská identita a její nové dimenze

open access: yesAntropoWebzin, 2011
The theme is crucial to the concrete question, whether moravian identity really exists. It´s about phenomena which is natural and important for some parts of population or on the other hand we can see this identity as the artificial problem.
Roman Iščuk
doaj  

The particularism of human rights discourse

open access: yes, 2023
The particularism of human rights ...
Patrick Emerton (13068927)
core  

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

open access: yesFEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda   +2 more
wiley   +1 more source

Nación y sociedad-mundo en la teoría de Niklas Luhmann y algunos de sus continuadores [PDF]

open access: yesAposta, 2017
El artículo desarrolla el concepto de ʻnaciónʼ en la teoría de la sociedad moderna de Niklas Luhmann, mostrando que, a pesar del estado rudimentario que tiene la temática en su planteo y la escasa importancia que le otorga para la comprensión de la ...
Lionel Lewkow
doaj  

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

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