Results 61 to 70 of about 5,357 (285)
"Vårt liv drar bort i förvandling"
Tidskrift för Litteraturvetenskap, 2015 ”Our Life Glides By in Transformation”. Literature and Scholarship in the Flux of Time This article – originally a sexagenarian lecture – first considers the transience of the inner life of human beings, bringing out the unique ability of literature ...
Torsten Pettersson
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The Jewish Judgement of Hannah Arendt
S: I. M. O. N., 2017 In June 2017, The Vienna Wiesenthal Institute (VWI) organised a joint workshop in Vienna with the International Research Centre for Cultural Sciences (IFK) on Hannah Arendt.
Natan Sznaider
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
In Defence of Particularism: A Reply to Stokes [PDF]
, 2016 A reply to Patrick Stokes' “Between Generalism and Particularism About Conspiracy Theory"
Dentith, Matthew R. X.
core +3 more sources
Crítica, 2017 This article analyzes the thesis of ethical relativism, as defended by Alchourrón and Bulygin (1983). These authors offer, on the one hand, a suggestive conception according to which the question “what are our obligations?” is equivalent to thinking ...
J.J. Moreso
doaj
Universalism and Particularism
, 2017 This chapter argues that current strands of the theories on international, supranational, and transnational law are on the road to leaving the dichotomy of universalism and particularism.
Armin von Bogdandy, Sergio Dellavalle
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