Results 61 to 70 of about 3,459 (300)
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
"Vårt liv drar bort i förvandling"
Tidskrift för Litteraturvetenskap, 2015 ”Our Life Glides By in Transformation”. Literature and Scholarship in the Flux of Time This article – originally a sexagenarian lecture – first considers the transience of the inner life of human beings, bringing out the unique ability of literature ...
Torsten Pettersson
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
A critical discussion of Jonathan Dancy's moral particularism
, 2007 'Moral Particularism' is a view that questions the role of principles in ethics. Jonathan Dancy, the most eminent particularist, argues that principles which claim that it is right or wrong to do a certain thing in all situations cannot adequately ...
Schwind, Philipp
core
Moral Particularism: An Introduction
, 2007 An introduction to a special edition of the Journal of Moral Philosophy on the subject of 'Moral Particularism'. I was the co-editor.
Kirchin, Simon T.
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Cadernos de Saúde Pública, 2002 Com base em uma discussão de autores contemporâneos sobre a formação histórica do Brasil e sua incorporação ao projeto de sociedade moderna, o artigo identifica duas formas de particularismo o das diferenças e o das relações pessoais que na esfera ...
Jeni Vaitsman
doaj +1 more source
Moral reasons : particularism, patterns and practice [PDF]
This is the study of the extent of the patternability of the reason-giving behaviour of morally relevant features in different ethical contexts. Whether or not the way in which a morally relevant feature contributes to the moral evaluation of different
Dabbagh, Sorush H.
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source