Results 51 to 60 of about 3,459 (300)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Historians, Memory Laws, and the Politics of the Past
European Papers, 2020 (Series Information) European Papers - A Journal on Law and Integration, 2020 5(1), 107-117 | Article | (Table of Contents) I. Historians against memory laws. - II. Historical memory and criminal law. - III. Universal values and particularistic memories.
Nikolay Koposov
doaj +1 more source
Particularism and Universalizability
The Journal of Value Inquiry, 2003 It is commonly assumed by particularists as well as by generalists that moral particularism is incompatible with the thesis of universalizability. Particularists, therefore, try to disprove the universalizability thesis, while generalists use the supposed incompatibility as an easy way to dismiss particularism.
openaire +2 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Universalism and Particularism
, 2017 This chapter argues that current strands of the theories on international, supranational, and transnational law are on the road to leaving the dichotomy of universalism and particularism.
Armin von Bogdandy, Sergio Dellavalle
core +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Moral emotions, principles, and the locus of moral perception
European Journal of Analytic Philosophy, 2006 I vindicate the thrust of the particularist position in moral deliberation. this purpose, I focus on some elements that seem to play a crucial role in first-person moral deliberation and argue that they cannot be incorporated into a more sophisticated ...
Joseph E. Corbi
doaj