Results 51 to 60 of about 5,357 (285)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Particularism and Universalizability

open access: yesThe Journal of Value Inquiry, 2003
It is commonly assumed by particularists as well as by generalists that moral particularism is incompatible with the thesis of universalizability. Particularists, therefore, try to disprove the universalizability thesis, while generalists use the supposed incompatibility as an easy way to dismiss particularism.
openaire   +2 more sources

Particularism, Perception and Judgement [PDF]

open access: yes, 2006
According to the most detailed articulation and defence of moral particularism, it is a metaphysical doctrine about the nature of reasons. This paper addresses aspects of particularist epistemology.
Smith, Benedict
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Moral emotions, principles, and the locus of moral perception

open access: yesEuropean Journal of Analytic Philosophy, 2006
I vindicate the thrust of the particularist position in moral deliberation. this purpose, I focus on some elements that seem to play a crucial role in first-person moral deliberation and argue that they cannot be incorporated into a more sophisticated ...
Joseph E. Corbi
doaj  

Particularism and Generalism Revisited: Towards a Principled Particularism of Contingency

open access: yes, 2020
This thesis will revisit the debate between moral particularists and moral generalists in the field of meta-ethics. The general aim of this project will be to come to a better understanding of the status and role of moral principles in a reasons-holistic
Thériault, Georges
core   +1 more source

Moral Particularism: An Introduction [PDF]

open access: yes, 2007
An introduction to a special edition of the Journal of Moral Philosophy on the subject of 'Moral Particularism'. I was the co-editor.
Kirchin, Simon T.
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

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