Results 71 to 80 of about 764,047 (274)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

partition function

, 2014
Citation: 'partition function' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.P04439 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +2 more sources

’t Hooft anomalies and the holomorphy of supersymmetric partition functions

Journal of High Energy Physics, 2019
We study the dependence of supersymmetric partition functions on continuous parameters for the flavor symmetry group, G F , for 2d N $$ \mathcal{N} $$ = (0, 2) and 4d N $$ \mathcal{N} $$ = 1 supersymmetric quantum field theories.
Cyril Closset, Lorenzo Di Pietro, Heeyeon Kim   +2 more
doaj   +1 more source

On the Wigner-Kirkwood Expansion of the Free Energy and the Evaluation of the Quantum Correction

Atoms, 2022
The Wigner-Kirkwood expansion of the quantum correction to the classical free energy is generally said to be in powers of ℏ2 and only its first few terms are presented.
Luc Kazandjian, François Soubiran, Jean-Christophe Pain   +2 more
doaj   +1 more source

Density Functional Partitions [PDF]

The Journal of Physical Chemistry, 1996
The performance of the local spin density approximation (LSD) of Kohn−Sham density functional theory when applied to partitioned electron densities has been explored. Spin partitioning and core/valence partitioning have each been examined and the results compared with conventional Moller−Plesset (MP2) theory based on the Kohn−Sham determinant.
John A. Pople, Ross D. Adamson, Peter M. W. Gill   +2 more
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Graviton 1-loop partition function for 3-dimensional massive gravity

, 2010
The graviton 1-loop partition function in Euclidean topologically massive gravity (TMG) is calculated using heat kernel techniques. The partition function does not factorize holomorphically, and at the chiral point it has the structure expected from a ...
A Maloney, A Maloney, AA Bytsenko, D Grumiller, D Grumiller, D Grumiller, Daniel Grumiller, DDK Chow, DDK Chow, Dmitri Vassilevich, DV Vassilevich, DV Vassilevich, E Elizalde, E Mottola, EA Bergshoeff, EA Bergshoeff, GW Gibbons, JR David, K Skenderis, M Bañados, M Flohr, Matthias R. Gaberdiel, MR Gaberdiel, MR Gaberdiel, MR Gaberdiel, R Camporesi, R Camporesi, RB Mann, S Carlip, S Carlip, S Deser, S Deser, S Ertl, S Giombi, V Gurarie, W Li   +35 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source