Results 51 to 60 of about 653,897 (318)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Molecular characterization of hepatitis C virus in liver disease patients in Botswana: a retrospective cross-sectional study

open access: yesBMC Infectious Diseases, 2019
Background Hepatitis C virus (HCV) infection is a major cause of chronic liver disease globally. Direct acting antivirals (DAAs) have proven effective in curing HCV.
Lynnette Bhebhe   +14 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Calgary Regional Partnership Municipalities of Black Diamond and Turner Valley get Funding Boost for Transit

open access: yes, 2017
The Calgary Regional Partnership municipalities of Black Diamond and Turner Valley will receive funding from the federal and provincial government for local transit.Calgary Regional ...
Calgary Regional Partnership
core   +1 more source

A qualitative assessment of barriers to iron and folic acid supplementation among pregnant women in Botswana

open access: yesBMC Public Health
Background Antenatal iron and folic acid (IFA) supplementation remains an effective strategy in the prevention of maternal anemia and low birthweight and is universally recommended by WHO. However, uptake of IFA has varied globally due to challenges with
Poloko Kebaabetswe   +11 more
doaj   +1 more source

Investigating disparities in cancer by linking the Canadian Cancer Registry to survey and administrative databases: a collaboration between the Canadian Partnership Against Cancer and Statistics Canada

open access: yesInternational Journal of Population Data Science, 2018
Introduction The Canadian Partnership Against Cancer reports on pan-Canadian system performance across the cancer control continuum, including how sociodemographic disparities create barriers in access and utilization of cancer control services. This has
Shirley Bryan   +6 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Calgary Regional Partnership Collaborates to Strengthen Economy with Emerging Trade Corridor to Port of Prince Rupert

open access: yes, 2017
For a second year, Calgary Regional Partnership (CRP) partnered with Prince Rupert Port Authority bringing together influential leaders from industry and government to plan for the development of an emerging trade corridor.Calgary Regional ...
Calgary Regional Partnership
core   +1 more source

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