Results 51 to 60 of about 961,049 (288)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

A qualitative assessment of barriers to iron and folic acid supplementation among pregnant women in Botswana

BMC Public Health
Background Antenatal iron and folic acid (IFA) supplementation remains an effective strategy in the prevention of maternal anemia and low birthweight and is universally recommended by WHO. However, uptake of IFA has varied globally due to challenges with
Poloko Kebaabetswe, Modiegi Diseko, Rebecca Zash, Gloria Mayondi, Judith Mabuta, Mompati Mmalane, Joseph Makhema, Shahin Lockman, Letumile Moeng, Elizabeth Lowenthal, Roger Shapiro, Ellen C. Caniglia   +11 more
doaj   +1 more source

Molecular characterization of hepatitis C virus in liver disease patients in Botswana: a retrospective cross-sectional study

BMC Infectious Diseases, 2019
Background Hepatitis C virus (HCV) infection is a major cause of chronic liver disease globally. Direct acting antivirals (DAAs) have proven effective in curing HCV.
Lynnette Bhebhe, Motswedi Anderson, Sajini Souda, Wonderful T. Choga, Edward Zumbika, Zachary M. Shaver, Tshepiso Mbangiwa, Bonolo B. Phinius, Chabeni C. Banda, Pinkie Melamu, Rosemary M. Musonda, Max Essex, Jason T. Blackard, Sikhulile Moyo, Simani Gaseitsiwe   +14 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Investigating disparities in cancer by linking the Canadian Cancer Registry to survey and administrative databases: a collaboration between the Canadian Partnership Against Cancer and Statistics Canada

International Journal of Population Data Science, 2018
Introduction The Canadian Partnership Against Cancer reports on pan-Canadian system performance across the cancer control continuum, including how sociodemographic disparities create barriers in access and utilization of cancer control services. This has
Shirley Bryan, Jasmine Tung, Jennifer Chadder, Cheryl Louzado, Yves Decady, Yubin Sung, Rami Rahal   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Vaccines in the fight against antimicrobial resistance – from evidence to policy - perspectives from South Africa

International Journal of Infectious Diseases
Introduction: The rising prevalence of drug-resistant infections presents a challenge to modern medicine by limiting life-saving therapeutic options, especially for those who cannot afford more expensive second-and third-line antibiotics, and ...
Dr Elloise Du Toit, Dr Erta Kalanxhi, Prof Adrian Brink, Ms Isabella Impalli   +3 more
doaj   +1 more source

An Uncertain Partnership [PDF]

Science, 2003
R esearch conducted at U.S. universities has contributed significantly to improvements in public health and national security. Currently, university scientists are diligently working to modify standard laboratory operating procedures to comply with regulations imposed under two new ...
openaire   +2 more sources