Results 61 to 70 of about 961,049 (288)

Partnership for Girls: Community Partnership Documents

, 2023
The Physical Activity Partnership for Girls was funded by the National Institute on Minority Health and Health Disparities (R24MD005096).This record includes documents that relate to the partnership agreements with local agencies that collaborated with ...
Latino Research Institute, Deborah Parra-Medina, Ph.D., M.P.H.   +1 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Pathways to improve health information systems in Ethiopia: current maturity status and implications

Health Research Policy and Systems, 2022
Background To achieve national and international strategic goals, countries are advised to assess the maturity status of their health information systems (HIS), including business continuity and interoperability.
Amanuel Biru, Dawit Birhan, Gemechis Melkamu, Abebaw Gebeyehu, Afrah Mohammedsanni Omer   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Rare detection of Wolbachia in Aedes aegypti and in Anopheles gambiae complex from Botswana

International Journal of Infectious Diseases
Introduction: Vector-borne diseases constitute a serious worldwide health risk, and effective, long-term management techniques are urgently required.
Ms Faith Tariro Hungwe, Mr Freddie Katlego Lame Rakwadi, Dr Sikhulile Moyo, Prof Giacomo Paganotti   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

State of India's Birds 2023: A framework to leverage semi‐structured citizen science for bird conservation

Ecosphere
Birds and their habitats are threatened with extinction around the world. Regional assessments of the “State of Birds” are a vital means to prioritize data‐driven conservation action by informing national and global policy.
Ashwin Viswanathan, Karthik Thrikkadeeri, Pradeep Koulgi, Praveen J., Arpit Deomurari, Ashish Jha, Ashwin Warudkar, Kulbhushansingh Suryawanshi, M. D. Madhusudan, Monica Kaushik, Naman Goyal, Rajah Jayapal, Suhel Quader, Sutirtha Dutta, Tarun Menon, Vivek Ramachandran   +15 more
doaj   +1 more source

Beyond metrics: relational dynamics and impacts of TB community funding

Frontiers in Public Health
Global funding for tuberculosis (TB) falls far short of estimated needs, often prioritizing commodities and service delivery. TB communities, including people affected by TB, remain underfunded and underrepresented in programme planning.
Anna Versfeld, Anna Versfeld, Caoimhe Smyth, Viorel Soltan, James Malar, Augusta Baiden, Liliana Caraulan   +6 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source