Results 61 to 70 of about 317,335 (268)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The Clinical and Economic Burden of Newly Diagnosed Hereditary Transthyretin (ATTRv) Amyloidosis: A Retrospective Analysis of Claims Data

Neurology and Therapy, 2020
Introduction Little is known about the burden of hereditary transthyretin (ATTRv) amyloidosis, a genetic, progressive, and fatal disease caused by extracellular deposition of transthyretin amyloid fibrils.
Sheila R. Reddy, Eunice Chang, Marian H. Tarbox, Michael S. Broder, Ryan S. Tieu, Spencer Guthrie, Montserrat Vera-Llonch, Michael R. Pollock   +7 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Residencia Dunelm en la Universidad de Durham, Inglaterra

Informes de la Construccion, 1969
La configuración externa del edificio fue uno de los factores que de modo más acusado influyó en el diseño de la «Dunelm House», cuyo mayor atractivo quizás sea su expresión formal escultórica.
Arquitectos Co. Partnership, Partners Ove Arup   +1 more
doaj   +1 more source

Governing Partnerships

, 2010
Public private partnerships (PPPs) are instruments of the public interest, yet bodies that actively engage private actors. As a result, questions of governance are particularly important. Here, governance refers to the rules that prescribe who should make, execute and be accountable for the conduct of a PPP, and in what way that conduct should be ...
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Malaria case investigation with reactive focal testing and treatment: operational feasibility and lessons learned from low and moderate transmission areas in Amhara Region, Ethiopia

Malaria Journal, 2018
Background When malaria transmission is very low, investigation of passively detected malaria cases and reactive focal testing and treatment (FTAT) in the case and neighbouring households can identify and contain the source and spread of infections ...
Pooja Bansil, Asnakew K. Yeshiwondim, Caterina Guinovart, Belendia Serda, Callie Scott, Berhane H. Tesfay, Adem Agmas, Belay Bezabih, Melkamu T. Zeleke, Girma S. Guesses, Asmamaw L. Ayenew, Worku M. Workie, Duncan Earle, Rick W. Steketee, Asefaw Getachew   +14 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Perinatal depression among women in pregnancy and postpartum periods in Gaborone, Botswana

BMC Pregnancy and Childbirth
Introduction Perinatal depression is an important cause of maternal and infant morbidity. Rates of perinatal depression amongst pregnant and postpartum women in Botswana are not well-documented.
Rebecca Ryan, Aamirah Mussa, Chibuzor M. Babalola, Emily Hansman, Selebaleng Simon, Bame Bame, Neo Ndlovu, Lefhela Tamuthiba, Jeffrey D. Klausner, Chelsea Morroni, Adriane Wynn   +10 more
doaj   +1 more source

A Federated Data Linkage Strategy to Support Population Health Research in Canada

International Journal of Population Data Science, 2017
Objectives Canada has established a pan-Canadian cohort with over 300,000 volunteer participants aged 35-69, to support research on cancer and chronic disease. A key feature of the cohort is that participants have consented to link their cohort data with
Tanya Flanagan, Céline Moore, Carolyn Sandoval   +2 more
doaj   +1 more source