Results 81 to 90 of about 961,049 (288)

Perinatal depression among women in pregnancy and postpartum periods in Gaborone, Botswana

BMC Pregnancy and Childbirth
Introduction Perinatal depression is an important cause of maternal and infant morbidity. Rates of perinatal depression amongst pregnant and postpartum women in Botswana are not well-documented.
Rebecca Ryan, Aamirah Mussa, Chibuzor M. Babalola, Emily Hansman, Selebaleng Simon, Bame Bame, Neo Ndlovu, Lefhela Tamuthiba, Jeffrey D. Klausner, Chelsea Morroni, Adriane Wynn   +10 more
doaj   +1 more source

Malaria case investigation with reactive focal testing and treatment: operational feasibility and lessons learned from low and moderate transmission areas in Amhara Region, Ethiopia

Malaria Journal, 2018
Background When malaria transmission is very low, investigation of passively detected malaria cases and reactive focal testing and treatment (FTAT) in the case and neighbouring households can identify and contain the source and spread of infections ...
Pooja Bansil, Asnakew K. Yeshiwondim, Caterina Guinovart, Belendia Serda, Callie Scott, Berhane H. Tesfay, Adem Agmas, Belay Bezabih, Melkamu T. Zeleke, Girma S. Guesses, Asmamaw L. Ayenew, Worku M. Workie, Duncan Earle, Rick W. Steketee, Asefaw Getachew   +14 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Federated Data Linkage Strategy to Support Population Health Research in Canada

International Journal of Population Data Science, 2017
Objectives Canada has established a pan-Canadian cohort with over 300,000 volunteer participants aged 35-69, to support research on cancer and chronic disease. A key feature of the cohort is that participants have consented to link their cohort data with
Tanya Flanagan, Céline Moore, Carolyn Sandoval   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Fitness to Drive Policy in Inpatient Setting: Findings of QI Project

BJPsych Open
Aims Background: Nature and degree of mental illness can impair abilities of patients to drive safely which puts their own safety and safety of others at risk.
Sajid Mahmood, Heba Radwan, Omotilewa Omotoso, Waqqas Khokhar, Nosheen Shams   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Governing Partnerships

, 2010
Public private partnerships (PPPs) are instruments of the public interest, yet bodies that actively engage private actors. As a result, questions of governance are particularly important. Here, governance refers to the rules that prescribe who should make, execute and be accountable for the conduct of a PPP, and in what way that conduct should be ...
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source