Results 101 to 110 of about 653,897 (318)

Partnership, high performance work systems and quality of working life [PDF]

, 2008
The paper measures the effects of workplace partnership and selected high performance work practices on four different dimensions of employee experience. Whilst the partnership-high performance work systems nexus seems to have little impact on employees'
Upchurch, Martin, Paul Stewart, Danford, A., Tailby, S., Tailby, Stephanie, Richardson, M., Martin Upchurch, Stewart, Paul, Mike Richardson, Andy Danford, Stewart, P., Stephanie Tailby, Richardson, Mike, Danford, Andy   +13 more
core   +1 more source

Fitness to Drive Policy in Inpatient Setting: Findings of QI Project

BJPsych Open
Aims Background: Nature and degree of mental illness can impair abilities of patients to drive safely which puts their own safety and safety of others at risk.
Sajid Mahmood, Heba Radwan, Omotilewa Omotoso, Waqqas Khokhar, Nosheen Shams   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Partnership for governance reform in Indonesia

, 2004
ix+65hlm ...
PARTNERSHIP
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The open government partnership: what are the challenges and opportunities for New Zealand? [PDF]

, 2014
In November 2013 New Zealand signed up to the Open Government Partnership (OGP), which was established in 2011 and comprises 63 nations. The OGP operates as a partnership on two levels: nationally, as a partnership between governments and civil society ...
Macaulay, Michael, Michael Macaulay
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Calgary Regional Partnership TRANSIT TEST PILOT: DRAFT SUB-REGIONAL FEASIBILITY STUDY OPERATIONAL PLAN

, 2018
The Calgary Region is growing rapidly. It is estimated that approximately another 1.8 million new residents will move to the Calgary Region within the next 50 years. Growth is good for the economy and brings with it advantages and challenges that need to
Calgary Regional Partnership, Stantec Consulting Ltd.   +1 more
core   +1 more source

Knowledge mobilisation for chronic disease prevention: the case of the Australian Prevention Partnership Centre

Health Research Policy and Systems, 2018
Background Cross-sectoral, multidisciplinary partnership research is considered one of the most effective means of facilitating research-informed policy and practice, particularly for addressing complex problems such as chronic disease.
Sonia Wutzke, Samantha Rowbotham, Abby Haynes, Penelope Hawe, Paul Kelly, Sally Redman, Seanna Davidson, Jackie Stephenson, Marge Overs, Andrew Wilson   +9 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source